479422-01-0 Usage
Uses
Used in Pharmaceutical and Chemical Research:
4,5-dichloro-2-methyl-1H-indole serves as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. It is used as a building block for [the creation of new drugs and organic molecules] due to its unique chemical structure and reactivity.
Used in Biological Research:
In the field of biological research, 4,5-dichloro-2-methyl-1H-indole is utilized as a subject of study for its potential biological activities. It is used as a research compound for [exploring its anti-inflammatory properties] and [its role in cancer research], given its chemical properties that may contribute to these areas of study.
Used in Drug Development:
4,5-dichloro-2-methyl-1H-indole is employed in drug development as a precursor molecule for [the development of new therapeutic agents]. Its specific structural features make it a valuable component in the design and synthesis of innovative drugs targeting various diseases and conditions.
Used in Organic Synthesis:
In the realm of organic synthesis, 4,5-dichloro-2-methyl-1H-indole is used as a reactant for [the formation of complex organic molecules]. Its reactivity and structural attributes allow for the creation of a wide array of organic compounds with diverse applications.
Check Digit Verification of cas no
The CAS Registry Mumber 479422-01-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,9,4,2 and 2 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 479422-01:
(8*4)+(7*7)+(6*9)+(5*4)+(4*2)+(3*2)+(2*0)+(1*1)=170
170 % 10 = 0
So 479422-01-0 is a valid CAS Registry Number.
479422-01-0Relevant academic research and scientific papers
Inhibition of cytosolic phospholipase A2α: Hit to lead optimization
McKew, John C.,Foley, Megan A.,Thakker, Paresh,Behnke, Mark L.,Lovering, Frank E.,Sum, Fuk-Wah,Tam, Steve,Wu, Kun,Shen, Marina W. H.,Zhang, Wen,Gonzalez, Mario,Liu, Shanghao,Mahadevan, Anu,Sard, Howard,Khor, Soo Peang,Clark, James D.
, p. 135 - 158 (2007/10/03)
Compound 1 was previously reported to be a potent inhibitor of cPLA 2α in both artificial monomeric substrate and cell-based assays. However, 1 was inactive in whole blood assays previously used to characterize cyclooxygenase and lipoxygenase inhibitors. The IC50 of 1 increased dramatically with cell number or lipid/detergent concentration. In an attempt to insert an electrophilic ketone between the indole and benzole acid moieties, we discovered that increasing the distance between the two moieties gave a compound with activity in the GLU (7-hydroxycoumarinyl-γ- linolenate) micelle assay, which contains lipid and detergent. Extensive structure-activity relationship work around this lead identified a potent pharmacophore for cPLA2α inhibition. The IC50s between the GLU micelle and rat whole blood assays correlated highly. No correlation was found for other parameters, including lipophilicity or acidity of the required acid functionality. Compounds 25, 39, and 94 emerged as potent, selective inhibitors of cPLA2α and represent well-validated starting points for further optimization.
