479483-98-2

Upstream product

• 139192-48-6 (S)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide 
• 72-18-4 L-valine 
• 2026-48-4 (S)-valinol 
• 53346-05-7 (R)-2-benzyloxypropanal 
• 479483-89-1 Propionic acid (S)-3-methyl-2-(toluene-4-sulfonylamino)-butyl ester 

Downstream Products

• 131897-94-4 (2S,3S,4R)-4-(benzyloxy)-3-hydroxy-2-methylpentanoic acid 

Relevant academic research and scientific papers

Chelation-controlled ester-derived titanium enolate aldol reaction: Diastereoselective syn-aldols with mono- and bidentate aldehydes

A chelation-controlled and highly diastereoselective synthesis of syn-aldols is described. Aldol reaction of (S)-valinol-derived ester with a variety of aldehydes proceeded with high syn-diastereoselectivities (up to 99:1) and isolated yields (94%).