479495-87-9Relevant academic research and scientific papers
High-affinity mu opioid receptor ligands discovered by the screening of an exhaustively stereodiversified library of 1,5-enediols
Harrison, Bryce A.,Gierasch, Tiffany Malinky,Neilan, Claire,Pasternak, Gavril W.,Verdine, Gregory L.
, p. 13352 - 13353 (2007/10/03)
In this communication, we report the synthesis of an exhaustively stereodiversified library of 16 1,5-enediols (2) and the screening of these compounds for mu opioid receptor (MOR) binding. The stereochemical configuration of 2 strongly impacted the bindi
