479500-75-9

Upstream product

• 338414-90-7 5-hydroxymethyl-2-methylthio-1-phenylmethylimidazole 
• 98412-23-8 1-benzyl-2-mercapto-5-hydroxymethyl-imidazole 
• 403479-30-1 1-benzyl-2-(methylsulfanyl)imidazole-5-carboxylic acid 
• 479400-30-1 1-benzyl-2-(methylsulfanyl)imidazole-5-carbaldehyde 
• 741668-58-6 1-benzyl-2-methylsulfanylimidazole-5-carbonyl chloride 
• 479500-74-8 1-benzyl-2-methylsulfanylimidazole-5-carboxylic acid methyl ester 

Downstream Products

• 853068-18-5 1-benzylidene-2-(1-benzyl-2-methylsulfanylimidazole-5-carbonyl)hydrazine 

Relevant academic research and scientific papers

Synthesis of Novel N-Substituted Imidazolecarboxylic Acid Hydrazides as Monoamine Oxidase Inhibitors

Novel 2-alkylsulfanyl-1-benzyl-5-imidazolecarboxylic acid hydrazides (15a,b) were synthesized as analogues of isocarboxazide, which is a known nonselective irreversible monoamine oxidase inhibitor and tested for monoamine oxidase A and B inhibitory activity. Neither of the compounds showed any inhibition of MAO B activity up to a high concentration of 100 μM. An MAO A activity was only slowly inhibited at this high concentration after prolonged incubation with either compound. This suggests any observed inhibition is not very specific.

Syntheses of substituted 2-(2-alkylthio-1-benzyl-5-imidazolyl)-1,3,4-oxadiazoles

Starting from the readily available benzylamine hydrochloride a series of 2-(2-alkylthio-1-benzyl-5imidazolyl)-1,3,4-oxadiazoles were prepared.