479543-46-9 Usage
Uses
VX 702 is a p38 MAP kinase pathway inhibitor.
Biological Activity
Orally active, ATP-competitive inhibitor of p38α MAPK; also inhibits p38β (K D values are 3.7 and 17 nM respectively).
Check Digit Verification of cas no
The CAS Registry Mumber 479543-46-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,9,5,4 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 479543-46:
(8*4)+(7*7)+(6*9)+(5*5)+(4*4)+(3*3)+(2*4)+(1*6)=199
199 % 10 = 9
So 479543-46-9 is a valid CAS Registry Number.
InChI:InChI=1/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)
479543-46-9Relevant academic research and scientific papers
SOLID FORMS OF 2-(2, 4-DIFLUOROPHENYL)-6-(1-(2,6-DIFLUOROPHENYL)UREIDO)NICOTINAMIDE
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Page/Page column 54-55, (2010/09/03)
This invention relates to solid forms of 2-(2, 4-difluorophenyl)-6-(l- (2,6-difluorophenyl)ureido)nicotinamide and pharmaceutical compositions thereof, and methods and uses therewith.
PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES)
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Page/Page column 26, (2010/09/03)
The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(l-(phenyl)ureido)nicotinamides in
