479544-52-0Relevant academic research and scientific papers
First example of an antibody-catalyzed aza Diels-Alder reaction.
Shi, Zhen-Dan,Yang, Bing-Hui,Wu, Yu-Lin,Pan, Ya-Juan,Ji, Yong-Yong,Yeh, Ming
, p. 2321 - 2324 (2002)
Described herein is the synthesis of a hapten of biocyclo[2,2,2]octene 5 designed to mimic the exo transition-state of an aza Diels-Alder reaction. Immunization of rabbits with this hapten provided polyclonal antibodies, Aza-BSA-3, which were used to synthesize adduct 4b in the first reported antibody-catalyzed exo Diels-Alder reaction.
