479578-07-9

Upstream product

• 354147-45-8 (1R)-1-phenyl-2-((1R')-1'-phenylethyl)-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine 
• 313963-79-0 1-((R)-phenyl-(((R)-1-phenylethyl)amino)methyl)naphthalen-2-ol 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 479578-05-7 1-{(R)-[N-methyl-((1'R)-1'-phenylethyl)amino](phenyl)methyl}naphthalen-2-ol 

Downstream Products

• 479578-08-0 {(R)-[2-(diphenylphosphinoyl)naphthalen-1-yl](phenyl)methyl}methyl((1R')-1'-phenylethyl)amine 
• 479578-14-8 {(R)-[2-(di-p-tolylphosphinoyl)naphthalen-1-yl](phenyl)methyl}methyl((1R')-1'-phenylethyl)amine 

Relevant academic research and scientific papers

Synthesis of a new type of chiral amino phosphine ligands for asymmetric catalysis

This article describes the synthesis of a new type of chiral amino phosphine ligands from an amino naphthol starting material derived by asymmetric 1-aminoalkylation of 2-naphthol with (R)-1-phenylethylamine and benzaldehyde. The asymmetric induction properties of the ligands in the Pd(0)-catalyzed allylic substitution of 1,3-diphenylprop-2-en-1-yl acetate with dimethyl malonate has also been investigated, with near-quantitative yields and ee of up to 72.2% of the product being obtained under the optimized reaction conditions.