479581-06-1Relevant academic research and scientific papers
Synthesis of aroylguanidines by an unexpected demethylation-addition cascade
Gu, Ling Hui,Guo, Zhen,He, Ling,Qi, Qing Rong
, p. 2533 - 2544 (2013/09/24)
A simple and efficient method was developed for the synthesis of N-aroyl-N′-arylguanidines under mild conditions by an unexpected demethylation-addition cascade reaction of readily available N-cyanoimidates with aryl amines. Moreover, 1-aryl-2-aminoquinazolin-4(1H)-ones and 2-(arylamino)quinazolin-4(3H)-ones can also be prepared by selective cyclization reactions of (2-fluorobenzoyl)- or (2-nitrobenzoyl)guanidines, respectively. This method provided two attractive strategies for the preparation 2-aminoquinazolinones derivatives from inexpensive reactants.
