479633-83-5Relevant academic research and scientific papers
DNA modification by cis-diaminoplatinum(II) complexes with aminonitroxide ligands
Sen',Shugalii,Kulikov
, p. 1058 - 1064 (2002)
The mixed-ligand complexes cis-ptII[R(CH2) nNH2](NH3)X2, where R = 2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl, X2 = ClI or Cl 2, n = 1 or 2, and binuclear complexes trans-3,4-bis[cis-ammine(iodochloro or dichloro)platinum(II)amino]-2,2,6,6-tetramethylpiperidin-1-oxyls were synthesized. The reactivity of the aminonitroxide complexes toward DNA, the destabilizing effect of the adducts on DNA structure, and the distribution of the Pt adducts along the DNA duplex were studied. The platination activity of the complexes is affected by the natures of both the leaving ligands X and the carrying amino ligands. The decrease in the platination activity of the complexes with an increase in the amino ligand sizes is probably caused by steric hindrance. The complexes that effectively platinate isolated DNA and cause a moderate destabilizition of DNA duplex possess high antitumor activities.
