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Jacoline, a pyrrolizidine alkaloid, is found in Senecio Jacobea, commonly known as tansy ragwort. It has a specific rotation of [α]20D +48° (CHC13) and can be hydrolyzed by alkalies to form retronecine and jacolinecic acid. Jacolinecic acid contains three hydroxyl and three methyl groups. It is a potentially carcinogenic, mutagenic, and teratogenic hepatotoxic alkaloid.

480-76-2

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480-76-2 Usage

Uses

1. Used in Pharmaceutical Research:
Jacoline is used as a research compound for studying its potentially harmful effects on the liver and its carcinogenic, mutagenic, and teratogenic properties. This helps in understanding the risks associated with its presence in the nectar of tansy ragwort and developing strategies to mitigate its harmful effects.
2. Used in Toxicology Studies:
Jacoline is used as a toxicological agent to study its impact on human and animal health. This helps in understanding the mechanisms of its toxicity and developing potential treatments or antidotes for poisoning caused by tansy ragwort.
3. Used in Plant Research:
Jacoline is used in the study of the tansy ragwort plant (Senecio Jacobea) to understand its chemical composition and the role of pyrrolizidine alkaloids in its defense mechanisms against herbivores and pathogens.
4. Used in Environmental and Ecological Studies:
Jacoline is used in research related to the ecological impact of tansy ragwort on the environment, as its presence in the nectar can have harmful effects on pollinators and other organisms that come into contact with the plant.
5. Used in Regulatory and Safety Assessments:
Jacoline is used in the assessment of safety regulations and guidelines for the management and control of tansy ragwort, considering its potential health risks to humans and animals.

References

Bradbury, Culvenor., Chern. & Ind., 1021 (1954)Bradbury, Culvenor., Austral. J. Chern., 7,378 (1954)Bradbury, Willis., ibid, 9,258 (1956)Geissman" ibid, 12,247 (1959)

Check Digit Verification of cas no

The CAS Registry Mumber 480-76-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 0 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 480-76:
(5*4)+(4*8)+(3*0)+(2*7)+(1*6)=72
72 % 10 = 2
So 480-76-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H27NO7/c1-10-8-18(24,11(2)20)16(22)26-13-5-7-19-6-4-12(14(13)19)9-25-15(21)17(10,3)23/h4,10-11,13-14,20,23-24H,5-9H2,1-3H3

480-76-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (20R)-12,15,20-trihydroxy-(15αH)-15,20-dihydro-senecionane-11,16-dione

1.2 Other means of identification

Product number -
Other names jacoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:480-76-2 SDS

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