480-79-5Relevant articles and documents
A synthesis of senecionine, a representative of hepatoxic, macrocyclic pyrrolizidine alkaloids of retronecine type
Niwa,Sakata,Yamada
, p. 1990 - 1993 (2007/10/02)
Described is a synthesis of (-)-senecionine, the best-known hepatoxic, 12-membered pyrrolizidine alkaloid of retronecine type. Integerrinecic acid lactone methyl ester was converted into protected senecic acid, which was regioselectively coupled with (+)-retronecine, achieving the first synthesis of (-)-senecionine.
Total Synthesis of Optically Active Integerrimine, a Twelve-membered Dilactonic Pyrrolizidine Alkaloid of Retronecine Type
Niwa, Haruki,Miyachi, Yasuyoshi,Okamoto, Osamu,Uosaki, Youichi,Kuroda, Akio,et al.
, p. 393 - 412 (2007/10/02)
A total synthesis of the natural enantiomer of integerrimine (1), a twelve-membered dilactonic pyrrolizidine alkaloid of retronecine type has been achieved through the enantioselective synthesis and regioselective coupling of (+)-retronecine (4) and (+)-integerrinecic acid (methylthio)methyl ether (6).
Total synthesis of optically active integerrimine, a twelve-membered dilactonic pyrrolizidine alkaloid of retronecine type. III. Regioselective elaboration of the unsymmetrical twelve-membered dilactone and total synthesis of (-)-integerrimine
Niwa,Miyachi,Uosaki,et al.
, p. 4609 - 4610 (2007/10/02)
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