4800-57-1

Basic information

• Product Name: 2-iodo-1-methyl-1,2-dihydroquinoline
• CAS NO: 4800-57-1
• Molecular Formula: C₁₀H₁₀IN
• Molecular Weight: 271.0976
• Mol File: 4800-57-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 304.1°C at 760 mmHg
• Flash Point: 137.7°C
• Density: 1.72g/cm³
• Vapor Pressure: 0.000891mmHg at 25°C
• Refractive Index: 1.687
• CAS DataBase Reference: 2-iodo-1-methyl-1,2-dihydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodo-1-methyl-1,2-dihydroquinoline(4800-57-1)
• EPA Substance Registry System: 2-iodo-1-methyl-1,2-dihydroquinoline(4800-57-1)

Safety Data

• Hazardous Substances Data: 4800-57-1(Hazardous Substances Data)

Upstream product

• 612-62-4 2-Chloroquinoline 
• 74-88-4 methyl iodide 

Relevant articles and documents

Evaluation of the antidepressant therapeutic potential of isocyanine and pseudoisocyanine analogues of the organic cation decynium-22

Herein we describe the synthesis and evaluation of antidepressant properties of seven analogues (1–7) of the low affinity/high capacity transporter blocker decynium-22 (D-22). All analogues (1–7) were synthesized via base promoted coupling reactions between N-alkylated-2-methylquinolinium iodides or N-alkylated-4-methylquinolinium iodides and electrophilic N-alkylated-2-iodoquinolinium iodides. All final compounds were purified by re-crystallization or preparative HPLC and initial evaluation studies included; 1) screening for in vitro α1-adrenoceptor activity (a property that can lead to unwanted side-effects), 2) measuring antidepressant-like activity in a mouse tail suspension test (TST), and 3) measuring effects upon mouse locomotion. The results showed some analogues have lower affinities at α1-adrenoceptors compared to D-22 and showed antidepressant-like activity without the need for co-administration of SSRIs. Additionally, many analogues did not affect mouse locomotion to the same extent as D-22. Plans for additional evaluations of these promising analogues, including measurement of antidepressant-like activity with co-administration of selective serotonin re-uptake inhibitors (SSRIs), are outlined.

Chiral Polymethine Dyes, III. Synthesis and Spectroscopic Properties of an Unsymmetrical, Chiral Monomethine Cyanine Dye with Thiazolyl and Quinolinyl End Group

The synthesis of the unsymmetrical monomethine cyanine dye 6 in its monochiral (6a, b) and isochiral form (6c), first realized by Goetze in 1938, has been significantly improved and its spectroscopic properties have been studied.According to the synthetic