4801-79-0

Basic information

• Product Name: Z-LEU-NH2
• Synonyms: N-ALPHA-CARBOBENZOXY-L-LEUCINE AMIDE;Z-L-LEUCINE AMIDE;Z-LEU-NH2;CBZ-L-LEUCINE AMIDE;CBZ-Leu-NH2;Z-L-leucine amide≥ 98% (HPLC);Z-L-Leu-NH2;(S)-Benzyl (1-amino-4-methyl-1-oxopentan-2-yl)carbamate
• CAS NO: 4801-79-0
• Molecular Formula: C₁₄H₂₀N₂O₃
• Molecular Weight: 264.32
• Mol File: 4801-79-0.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Z-LEU-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: Z-LEU-NH2(4801-79-0)
• EPA Substance Registry System: Z-LEU-NH2(4801-79-0)

Safety Data

• Hazardous Substances Data: 4801-79-0(Hazardous Substances Data)

Usage

General Description

Z-Leu-NH2, also known as Carbobenzoxy-L-leucinamide, is a chemical compound often used in scientific research. It falls into the category of specialty fine chemicals and is frequently utilized in biochemical applications, pharmaceutical and medicinal chemistry, particularly as a reagent in organic synthesis. Several drugs can be synthesized using this compound. Its molecular formula is C11H18N2O3, and it features carbobenzoxy and leucinamide moieties. Specific safety, handling, and storage requirements should be observed due to its potential hazardous properties.

Upstream product

• 2706-38-9 N-(N-benzyloxycarbonyl-L-leucyl)-glycine 
• 148854-04-0 (C₈H₇O₂)(NHCHCOO)(CH₂C₃H₇)(CO₂C₂H₅) 
• 2018-66-8 Z-Leu-OH 
• 543-27-1 isobutyl chloroformate 
• 501-53-1 benzyl chloroformate 
• 61-90-5 L-leucine 
• 158011-13-3 Z-Leu-Ser-Ser-Leu-Leu-Ser-Leu-OMe 
• 158011-07-5 Z-Leu-Ser-His-OMe 
• 102156-97-8 N-benzyloxycarbonyl-L-thioleucine S-phenyl ester 
• 4091-51-4 N-Benzyloxycarbonyl-L-leucin- 
• 87052-59-3 N-Z-Leucine chloride 
• 51021-87-5 N-benzyloxycarbonyl-L-leucine methyl ester 

Downstream Products

• 1003005-48-8 N-((E)-1-propylpent-1-enyl)(2S)-4-methyl-2-[(phenylmethoxy)carbonylamino]pentanamide 
• 13139-30-5 (S)-2-benzyloxycarbonylamino-4-methyl-pentanimidic acid ethyl ester 
• 1314777-93-9 (S,Z)-benzyl 1-(1-hydroxybut-2-en-2-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate 
• 228557-26-4 benzyl N-[1-(aminomethyl)-3-methyl-butyl]carbamate 

Relevant articles and documents

Synthesis of Terminal Thiazoles from N-Protected Amino Acids and a Study of Their Antibacterial Activities

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β,γ-Diamino acid: An original building block for hybrid α/γ-peptide synthesis with extra hydrogen bond donating group

Using a β,γ-diamino acid, several small hybrid α/γ peptides have been synthesized and their conformations investigated through extensive NMR studies and molecular dynamics. A tripeptide and a tetrapeptide have thus shown several hydrogen bonds in solution, including a 13-membered ring involving the β-nitrogen.

AmIno Acid Homologation by the Blaise Reaction: A new entry into nitrogen heterocycles

(Chemical Equation Presented) A general strategy for the amino acid homologation via Blaise reaction and subsequent reduction is presented. This strategy involves the preparation of protected α-amino nitriles from the corresponding amino acids, followed by the zinc-mediated condensation of tert-butyl bromoacetate, to give the imidazolidones after iminozincate cyclization. Reduction gave the saturated imidazolidinones with cis or trans stereochemistry, depending on the reduction conditions. This strategy was applied to nonfunctionalized amino acids and to functionalized amino acids such as serine and aspartic acid. Additionally, acidic hydrolysis of cis or trans imidazolidinones to the corresponding chiral 4-aminopyrrolidones is described.