48014-95-5Relevant academic research and scientific papers
Studies on the Activation Pathway of Phosphonic acid using Acyl Chlorides as Activators
Stawinski, Jacek,Thelin, Mats
, p. 849 - 853 (2007/10/02)
The activation pathway of phosphonic acid with acyl chlorides has been investigated with the aim of evaluating the synthetic utility of the intermediates involved for the preparation of hydrogen-phosphonate (H-phosphonate) monoesters.It is found that, depending on the amount of condensing reagent used, three distinctive intermediates are potentially formed, namely the pyrophosphonate (2), the phosphono-acyl mixed anhydride (3a), and the triacyl phosphite (4a).Their chemical reactivities towards oxygen nucleophiles indicate that the most suitable intermediate for H-phosphonate monoester synthesis is the pyrophosphonate (2).
