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4803-57-0

5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 4803-57-0 Structure

  • Basic information

    1. Product Name: 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE
    2. Synonyms: 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE;5,6-Dimethoxy-2-(4-pyridylmethyl)-1-indanone;Donepezil Pyridine Analog IMpurity;Donepezil Pyridine IMpurity;Donepezil Impurity II (Donepezil Related Compound B(USP));5,6-dimethoxy-2-(pyridin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one;Donepezil pyridine analog;Donepezil Impurity N
    3. CAS NO:4803-57-0
    4. Molecular Formula: C17H17NO3
    5. Molecular Weight: 283.32178
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycles;Impurities
    8. Mol File: 4803-57-0.mol

  • Chemical Properties

    1. Melting Point: 190-191℃
    2. Boiling Point: 474.965°C at 760 mmHg
    3. Flash Point: 241.05°C
    4. Appearance: /
    5. Density: 1.208g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.59
    8. Storage Temp.: Refrigerator
    9. Solubility: Chloroform (Sparingly), Methanol (Slightly, Heated)
    10. PKA: 5.74±0.10(Predicted)
    11. CAS DataBase Reference: 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE(4803-57-0)
    13. EPA Substance Registry System: 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE(4803-57-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4803-57-0(Hazardous Substances Data)

4803-57-0 Usage

Uses

Donepezil (D531750) impurity.

Check Digit Verification of cas no

The CAS Registry Mumber 4803-57-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,0 and 3 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4803-57:
(6*4)+(5*8)+(4*0)+(3*3)+(2*5)+(1*7)=90
90 % 10 = 0
So 4803-57-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H17NO3/c1-20-15-9-12-8-13(7-11-3-5-18-6-4-11)17(19)14(12)10-16(15)21-2/h3-6,9-10,13H,7-8H2,1-2H3

4803-57-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6-dimethoxy-2-(pyridin-4-ylmethyl)-2,3-dihydroinden-1-one

1.2 Other means of identification

Product number -
Other names 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4803-57-0 SDS

4803-57-0Relevant articles and documents

Novel Process for Production of Highly Pure Polymorph (I) Donepezil Hydrochloride

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Page/Page column 7-8, (2009/01/20)

The present invention provides a novel, industrially realizable and economically preferable process for production of highly pure 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl piperidine hydrochloride, i.e., donepezil hydrochloride shown in the following reaction scheme, in Polymorph (I) morphological crystal form. (I) In one of the key steps of the process, during the hydrogenation 5,6-dimethoxy 2-(pyridine-4-yhnethylene)indan-1-one hydrochloride is saturated using Pd carbon to get 4-[(5,6-dimethoxy-1-indanon)-2-yl]-methyl piperidine at more than 97% HPLC purity. In the crystallization step donepezil-hydrochloride is crystallized from an aqueous alcoholic solvent to get Polymorph (I) in at least 99.95% HPLC purity.

New synthesis of donepezil through palladium-catalyzed hydrogenation approach

Elati, Chandrashekar R.,Kolla, Naveenkumar,Chalamala, Subrahmanyeswara Rao,Vankawala, Pravinchandra J.,Sundaram, Venkataraman,Vurimidi, Himabindu,Mathad, Vijayavitthal T.

, p. 169 - 174 (2007/10/03)

A new, economical, and efficient process has been developed for large-scale synthesis of donepezil 1, an anti-Alzheimer's drug. The process involves palladium-catalyzed hydrogenation of (2E)-5,6-dimethoxy-2-(pyridin-4- ylmethylene)indan-1-one 6 to provide 5,6-dimethoxy-2-(piperidin-4-ylmethyl) indan-1-one 8 as a key step. Copyright Taylor & Francis LLC.

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