4803-57-0

Basic information

• Product Name: 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE
• Synonyms: 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE;5,6-Dimethoxy-2-(4-pyridylmethyl)-1-indanone;Donepezil Pyridine Analog IMpurity;Donepezil Pyridine IMpurity;Donepezil Impurity II (Donepezil Related Compound B(USP));5,6-dimethoxy-2-(pyridin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one;Donepezil pyridine analog;Donepezil Impurity N
• CAS NO: 4803-57-0
• Molecular Formula: C₁₇H₁₇NO₃
• Molecular Weight: 283.32178
• Product Categories: Aromatics;Heterocycles;Impurities
• Mol File: 4803-57-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 190-191℃
• Boiling Point: 474.965°C at 760 mmHg
• Flash Point: 241.05°C
• Appearance: /
• Density: 1.208g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Sparingly), Methanol (Slightly, Heated)
• PKA: 5.74±0.10(Predicted)
• CAS DataBase Reference: 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE(4803-57-0)
• EPA Substance Registry System: 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE(4803-57-0)

Safety Data

• Hazardous Substances Data: 4803-57-0(Hazardous Substances Data)

Usage

Uses

Donepezil (D531750) impurity.

InChI:InChI=1/C17H17NO3/c1-20-15-9-12-8-13(7-11-3-5-18-6-4-11)17(19)14(12)10-16(15)21-2/h3-6,9-10,13H,7-8H2,1-2H3

Upstream product

• 851385-19-8 2,3-dihydro-5,6-dimethoxy-2-((pyridin-4-yl)methylene)inden-1-one p-toluenesulfonic acid salt 
• 877606-65-0 (E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one 

Downstream Products

• 231283-82-2 (±)-2-[(1-benzylpyridin-1-ium-4-yl)methyl]-5,6-dimethoxy-indan-1-one bromide 
• 1620644-71-4 1-benzyl-4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2 yl)methyl)pyridinium iodide 
• 896134-07-9 4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]pyridine N-oxide 
• 120014-30-4 debenzyldonepezil 

Relevant articles and documents

Novel Process for Production of Highly Pure Polymorph (I) Donepezil Hydrochloride

The present invention provides a novel, industrially realizable and economically preferable process for production of highly pure 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl piperidine hydrochloride, i.e., donepezil hydrochloride shown in the following reaction scheme, in Polymorph (I) morphological crystal form. (I) In one of the key steps of the process, during the hydrogenation 5,6-dimethoxy 2-(pyridine-4-yhnethylene)indan-1-one hydrochloride is saturated using Pd carbon to get 4-[(5,6-dimethoxy-1-indanon)-2-yl]-methyl piperidine at more than 97% HPLC purity. In the crystallization step donepezil-hydrochloride is crystallized from an aqueous alcoholic solvent to get Polymorph (I) in at least 99.95% HPLC purity.