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4804-02-8

"O3'-acetyl-N4-benzoyl-O5'-(toluene-4-sulfonyl)-2'deoxy-cytidine" is a complex organic compound with a molecular formula of C28H27N3O10S. It is a modified nucleoside, derived from the naturally occurring nucleoside cytidine, with several functional groups attached to it. The "O3'-acetyl" group indicates an acetyl group attached to the 3' oxygen of the sugar moiety, the "N4-benzoyl" group signifies a benzoyl group attached to the nitrogen at the 4 position of the cytosine base, and the "O5'-(toluene-4-sulfonyl)" group indicates a toluene-4-sulfonyl group attached to the 5' oxygen of the sugar moiety. O3'-acetyl-N4-benzoyl-O5'-(toluene-4-sulfonyl)-2'deoxy-cytidine is of interest in the field of medicinal chemistry and may have potential applications in the development of new drugs, particularly in the area of antiviral therapy, due to its ability to interfere with nucleic acid synthesis.

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  • 4804-02-8 Structure

  • Basic information

    1. Product Name: O3'-acetyl-N4-benzoyl-O5'-(toluene-4-sulfonyl)-2'deoxy-cytidine
    2. Synonyms: O3'-acetyl-N4-benzoyl-O5'-(toluene-4-sulfonyl)-2'deoxy-cytidine
    3. CAS NO:4804-02-8
    4. Molecular Formula:
    5. Molecular Weight: 527.555
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 4804-02-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: O3'-acetyl-N4-benzoyl-O5'-(toluene-4-sulfonyl)-2'deoxy-cytidine(CAS DataBase Reference)
    10. NIST Chemistry Reference: O3'-acetyl-N4-benzoyl-O5'-(toluene-4-sulfonyl)-2'deoxy-cytidine(4804-02-8)
    11. EPA Substance Registry System: O3'-acetyl-N4-benzoyl-O5'-(toluene-4-sulfonyl)-2'deoxy-cytidine(4804-02-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4804-02-8(Hazardous Substances Data)

4804-02-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4804-02-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,0 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4804-02:
(6*4)+(5*8)+(4*0)+(3*4)+(2*0)+(1*2)=78
78 % 10 = 8
So 4804-02-8 is a valid CAS Registry Number.

4804-02-8Downstream Products

4804-02-8Relevant articles and documents

Synthesis and biological evaluation of triazolyl 13α-estrone-nucleoside bioconjugates

Bodnár, Brigitta,Mernyák, Erzsébet,W?lfling, János,Schneider, Gyula,Herman, Bianka Edina,Szécsi, Mihály,Sinka, Izabella,Zupkó, István,Kupihár, Zoltán,Kovács, Lajos

, (2016)

2' -Deoxynucleoside conjugates of 13α-estrone were synthesized by applying the copper-catalyzed alkyne-azide click reaction (CuAAC). For the introduction of the azido group the 5? -position of the nucleosides and a propargyl ether functional group on the 3-hydroxy group of 13α-estrone were chosen. The best yields were realized in our hands when the 3? -hydroxy groups of the nucleosides were protected by acetyl groups and the 5? -hydroxy groups were modified by the tosyl-azide exchange method. The commonly used conditions for click reaction between the protected-5? -azidonucleosides and the steroid alkyne was slightly modified by using 1.5 equivalent of Cu(I) catalyst. All the prepared conjugates were evaluated in vitro by means of MTT assays for antiproliferative activity against a panel of human adherent cell lines (HeLa, MCF-7 and A2780) and the potential inhibitory activity of the new conjugates on human 17β-hydroxysteroid dehydrogenase 1 (17β-HSD1) was investigated via in vitro radiosubstrate incubation. Some protected conjugates displayed moderate antiproliferative properties against a panel of human adherent cancer cell lines (the protected cytidine conjugate proved to be the most potent with IC50 value of 9 μM). The thymidine conjugate displayed considerable 17β-HSD1 inhibitory activity (IC50 = 19 μM).

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