480424-72-4

Basic information

• Product Name: (5S)-5-(HYDROXYMETHYL)-3-((1R)-1-PHENYL&
• Synonyms: (5S)-5-(HYDROXYMETHYL)-3-((1R)-1-PHENYL&;3-(1'(R)-ALPHA-METHYLBENZYL)-5(S)-HYDRO&;(s)-5-(hydroxymethyl)-3-[(r)-α-methylbenzyl-2-oxazolidinone;3-(1μ-(R)-α-Methylbenzyl)-5(S)-hydroxymethyl-oxazolidin-2-one, (S)-5-(Hydroxymethyl)-3-[(R)-α-methylbenzyl-2-oxazolidinone
• CAS NO: 480424-72-4
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.255
• Mol File: 480424-72-4.mol

Chemical Properties

• Melting Point: 116-120 °C(lit.)
• Boiling Point: 444.4°C at 760 mmHg
• Flash Point: 222.6°C
• Appearance: /
• Density: 1.219g/cm³
• Vapor Pressure: 1.12E-08mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: (5S)-5-(HYDROXYMETHYL)-3-((1R)-1-PHENYL&(CAS DataBase Reference)
• NIST Chemistry Reference: (5S)-5-(HYDROXYMETHYL)-3-((1R)-1-PHENYL&(480424-72-4)
• EPA Substance Registry System: (5S)-5-(HYDROXYMETHYL)-3-((1R)-1-PHENYL&(480424-72-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 480424-72-4(Hazardous Substances Data)

Usage

Uses

As the specific uses of (5S)-5-(HYDROXYMETHYL)-3-((1R)-1-PHENYL& are not provided in the materials, it is not possible to list its applications or the reasons for those applications. Further research and exploration would be necessary to identify potential uses in various industries, such as pharmaceuticals, organic synthesis, or other chemical applications.

InChI:InChI=1/C12H15NO3/c1-9(10-5-3-2-4-6-10)13-7-11(8-14)16-12(13)15/h2-6,9,11,14H,7-8H2,1H3/t9-,11+/m1/s1

Upstream product

• 113420-77-2 (1'S^*,5S^*)-3-(1'-phenyleth-1'yl)-5-(iodomethyl)oxazolidin-2-one 
• 113420-76-1 (S)-N-(1-phenyleth-1-yl)-N-(prop-2-en-1-yl)amine hydrobromide 
• 113471-09-3 (S)-N-(1-phenyleth-1-yl)-N-(prop-2-en-1-yl)-N-(benzyloxycarbonyl)amine 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 595549-63-6 (5R)-3-[(1S)-1-phenylethyl]-5-vinyl-1,3-oxazolidin-2-one 
• 113420-78-3 (1'S^*,5S^*)-3-(1'-phenyleth-1'-yl)-5-(acetoxymethyl)oxazolidin-2-one 
• 113420-83-0 (1'S^*,5R^*)-3-(1'-phenyleth-1'yl)-5-(iodomethyl)oxazolidin-2-one 
• 113420-84-1 (1'S^*,5R^*)-3-(1'-phenyleth-1'-yl)-5-(acetoxymethyl)oxazolidin-2-one 

Downstream Products

• 637343-57-8 (5R)-Azidomethyl-3-[(1R)-phenylethyl-oxazolidine-2-one] 

Relevant articles and documents

A simple and easy access to 3-N-alkyl-5-vinyloxazolidinones mediated by palladium-phosphine catalysts

A new entry for the synthesis of 3-alkyl substituted 5-vinyloxazolidin-2-one derivatives 2 from cis-2-butenylene-1,4-dicarbonate 1 and primary amines mediated by palladium-phosphine catalysts is described. The scope and limitation, a plausible mechanism, and an asymmetric version of the reaction are also discussed.

AN EFFICIENT SYNTHESIS OF (R)-(+)- AND (S)-(-)-PROPRANOLOL FROM RESOLVED 5-IODOMETHYLOXAZOLIDIN-2-ONES

(1'S*,5S,R)-3-(1'-phenyleth-1'-yl)-5-iodomethyloxazolidin-2-ones, 4a,b, have been synthesized and easily resolved by silica gel chromatography.Each pure diastereomer has been then converted to (S)-(-)-propranolol 1a and (R)-(+)-propranolol 1b, respectively.An empirical correlation of configuration and 1H NMR chemical shift for alternate diastereomers has been devised and has proved to be applicable in assigning the configuration of 5-substituted 3-(1'-phenyleth-1'-yl)oxazolidin-2-ones.