480438-92-4

Usage

Uses

Used in Organic and Organometallic Synthesis:
(2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL& is used as a versatile precursor in the synthesis of silicon-containing molecules and materials, playing a crucial role in the development of new compounds and materials with potential applications in various fields.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL& is used as a reagent in various chemical reactions, such as cross-coupling, hydrosilylation, and cyclization reactions, to create new drug candidates with improved properties and therapeutic effects.
Used in Agrochemical Industry:
(2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL& is also utilized in the agrochemical industry for the synthesis of novel agrochemicals, including pesticides and herbicides, with enhanced efficacy and selectivity.
Used in Materials Science:
In the field of materials science, (2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL& is employed in the development of advanced materials with unique properties, such as improved thermal stability, mechanical strength, and electrical conductivity, for use in various applications, including electronics, aerospace, and automotive industries.

InChI:InChI=1/C11H12F2Si/c1-14(2,3)7-6-9-4-5-10(12)8-11(9)13/h4-5,8H,1-3H3

Upstream product

• 996-50-9 N,N-diethyl-1,1,1-trimethylsilanamine 
• 302912-34-1 2,4-difluoroethynylbenzene 
• 2265-93-2 2,4-difluoro-1-iodobenzene 
• 1066-54-2 trimethylsilylacetylene 
• 348-57-2 2,4-difluorobromobenzene 

Downstream Products

• 915771-99-2 Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-(2,4-difluoro-phenylethynyl)-3,6-dihydro-2H-pyran-3-yl ester 
• 915772-51-9 [(2R,3S,6S)-6-(2,4-Difluoro-phenylethynyl)-3-(4-methoxy-phenoxy)-3,6-dihydro-2H-pyran-2-yl]-methanol 
• 915772-30-4 Carbonic acid (2R,3S,6S)-6-(2,4-difluoro-phenylethynyl)-2-ethoxycarbonyloxymethyl-3,6-dihydro-2H-pyran-3-yl ester ethyl ester 
• 1355996-94-9 1,3,5-tris{[4-(2,4-difluorophenyl)-1H-1,2,3-triazol-1-yl]methyl}benzene 
• 1311386-87-4 4-(1-(2,4-difluorophenyl))-1-benzyl-1,2,3-triazole 
• 302912-34-1 2,4-difluoroethynylbenzene 

Relevant academic research and scientific papers

Inverting Conventional Chemoselectivity in the Sonogashira Coupling Reaction of Polyhalogenated Aryl Triflates with TMS-Arylalkynes

A newly developed phosphine ligand with a C2-cyclohexyl group on the indole ring was successfully applied in a chemoselective Sonogashira coupling reaction with excellent chemoselectivity, affording an inversion of the conventional chemoselectivity order of C–Br > C–Cl > C–OTf. This study also provided an efficient approach to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and the natural product analogue trimethyl-selaginellin L by merging of chemoselective Sonogashira and Suzuki–Miyaura coupling reactions.

Synthesis and Photochemical Application of Hydrofluoroolefin (HFO) Based Fluoroalkyl Building Block

A novel fluoroalkyl iodide was synthesized on multigram scale from refrigerant gas HFO-1234yf as cheap industrial starting material in a simple, solvent-free, and easily scalable process. We demonstrated its applicability in a metal-free photocatalytic ATRA reaction to synthesize valuable fluoroalkylated vinyl iodides and proved the straightforward transformability of the products in cross-coupling chemistry to obtain conjugated systems.

Copper-Catalyzed Ring Opening of [1.1.1]Propellane with Alkynes: Synthesis of Exocyclic Allenic Cyclobutanes

Despite the long history and interesting properties of propellanes, these compounds still have tremendous potential to be exploited in synthetic organic chemistry. Herein we disclose an experimentally simple procedure to achieve cyclobutane-containing allenes and alkynes through a copper-catalyzed ring opening of [1.1.1]propellane and subsequent reaction with ethynes.

One-pot click synthesis of 1N-alkyl-4-aryl-1,2,3-triazoles from protected arylalkynes and alkyl bromides

1N-Alkyl-4-aryl-1,2,3-triazoles have been prepared through a multicomponent one-pot protocol from the corresponding (arylethynyl)trimethylsilanes and alkyl bromides. In situ alkyl azide formation and alkyne deprotection followed by copper(I)-catalyzed click cycloaddition afforded the desired 1,4-disubstituted 1,2,3-triazoles in generally good to excellent yield, with only minor observation of the undesired 1,5-regioisomeric cycloadduct. The protocol eliminates the need to use reactive organic azides and terminal alkynes. Georg Thieme Verlag Stuttgart. New York.

Exploring skeletal diversity via ring contraction of glycal-derived scaffolds

(Chemical Equation Presented) Aryl ether C-glycoside scaffolds have been prepared from tri-O-acetyl-D-glucal by C-glycosylation followed by allylic substitution with phenols mediated by Pd(0). The aryl ethers were subjected to either [3,3]-sigmatropic rea