480438-92-4

Basic information

• Product Name: (2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL&
• Synonyms: (2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL&
• CAS NO: 480438-92-4
• Molecular Formula: C₁₁H₁₂F₂Si
• Molecular Weight: 210.298
• Product Categories: Alkynyl;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 480438-92-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 85 °C0.1 mm Hg(lit.)
• Flash Point: 195 °F
• Appearance: /
• Density: 1.005 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.493mmHg at 25°C
• Refractive Index: n20/D 1.4960(lit.)
• CAS DataBase Reference: (2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL&(CAS DataBase Reference)
• NIST Chemistry Reference: (2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL&(480438-92-4)
• EPA Substance Registry System: (2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL&(480438-92-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 480438-92-4(Hazardous Substances Data)

Usage

General Description

The chemical compound (2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSILANE is a silicon-based organic compound with a molecular formula of C12H11F2Si. It features a triple bond between a carbon atom and a silicon atom and two fluorine atoms attached to a phenyl ring, making it a member of the alkynylsilane family. (2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL& is mainly used in organic and organometallic synthesis as a versatile precursor for the construction of silicon-containing molecules and materials. Additionally, it can serve as a reagent in various chemical reactions, including cross-coupling, hydrosilylation, and cyclization reactions. Due to its unique structure and reactivity, (2 4-DIFLUOROPHENYLETHYNYL)TRIMETHYLSILANE has found applications in the pharmaceutical, agrochemical, and materials science industries.

InChI:InChI=1/C11H12F2Si/c1-14(2,3)7-6-9-4-5-10(12)8-11(9)13/h4-5,8H,1-3H3

Upstream product

• 996-50-9 N,N-diethyl-1,1,1-trimethylsilanamine 
• 302912-34-1 2,4-difluoroethynylbenzene 
• 2265-93-2 2,4-difluoro-1-iodobenzene 
• 1066-54-2 trimethylsilylacetylene 
• 348-57-2 2,4-difluorobromobenzene 

Downstream Products

• 915771-99-2 Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-(2,4-difluoro-phenylethynyl)-3,6-dihydro-2H-pyran-3-yl ester 
• 1355996-94-9 1,3,5-tris{[4-(2,4-difluorophenyl)-1H-1,2,3-triazol-1-yl]methyl}benzene 
• 1311386-87-4 4-(1-(2,4-difluorophenyl))-1-benzyl-1,2,3-triazole 
• 302912-34-1 2,4-difluoroethynylbenzene 
• 915772-30-4 Carbonic acid (2R,3S,6S)-6-(2,4-difluoro-phenylethynyl)-2-ethoxycarbonyloxymethyl-3,6-dihydro-2H-pyran-3-yl ester ethyl ester 
• 915772-51-9 [(2R,3S,6S)-6-(2,4-Difluoro-phenylethynyl)-3-(4-methoxy-phenoxy)-3,6-dihydro-2H-pyran-2-yl]-methanol 

Relevant articles and documents

Inverting Conventional Chemoselectivity in the Sonogashira Coupling Reaction of Polyhalogenated Aryl Triflates with TMS-Arylalkynes

A newly developed phosphine ligand with a C2-cyclohexyl group on the indole ring was successfully applied in a chemoselective Sonogashira coupling reaction with excellent chemoselectivity, affording an inversion of the conventional chemoselectivity order of C–Br > C–Cl > C–OTf. This study also provided an efficient approach to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and the natural product analogue trimethyl-selaginellin L by merging of chemoselective Sonogashira and Suzuki–Miyaura coupling reactions.

Copper-Catalyzed Ring Opening of [1.1.1]Propellane with Alkynes: Synthesis of Exocyclic Allenic Cyclobutanes

Despite the long history and interesting properties of propellanes, these compounds still have tremendous potential to be exploited in synthetic organic chemistry. Herein we disclose an experimentally simple procedure to achieve cyclobutane-containing allenes and alkynes through a copper-catalyzed ring opening of [1.1.1]propellane and subsequent reaction with ethynes.

Exploring skeletal diversity via ring contraction of glycal-derived scaffolds

(Chemical Equation Presented) Aryl ether C-glycoside scaffolds have been prepared from tri-O-acetyl-D-glucal by C-glycosylation followed by allylic substitution with phenols mediated by Pd(0). The aryl ethers were subjected to either [3,3]-sigmatropic rea