4805-28-1

Upstream product

• 5336-50-5 1-benzyl-4,5-dioxopyrrolidine-3-carboxylic acid ethyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 100-46-9 benzylamine 
• 23583-21-3 ethyl-3-benzylamino propionate 
• 5336-41-4 methyl 1-benzyl-4,5-dioxopyrrolidine-3-carboxylate 

Downstream Products

• 1603163-24-1 2-benzyl-4-(4-chlorophenyl)-9a-hydroxy-5-nitro-2,3,3a,4,6,7,8,9a-octahydro-1H-imidazo[1,2-a]pyrrolo[3,4-e]pyridin-1-one 
• 1603163-26-3 2-benzyl-4-(4-chlorophenyl)-5-(4-fluorobenzoyl)-9a-hydroxy-2,3,3a,4,6,7,8,9a-octahydro-1H-imidazo[1,2-a]pyrrolo[3,4-e]pyridin-1-one 
• 1603163-33-2 2-benzyl-5-(4-chlorobenzoyl)-4-(4-chlorophenyl)-9a-hydroxy-2,3,3a,4,6,7,8,9a-octahydro-1H-imidazo[1,2-a]pyrrolo[3,4-e]pyridin-1-one 
• 1603163-37-6 5-benzoyl-2-benzyl-4-(4-chlorophenyl)-9a-hydroxy-2,3,3a,4,6,7,8,9a-octahydro-1H-imidazo[1,2-a]pyrrolo[3,4-e]pyridin-1-one 
• 1603163-41-2 2-benzyl-4-(4-chlorophenyl)-9a-hydroxy-5-(4-methylbenzoyl)-2,3,3a,4,6,7,8,9a-octahydro-1H-imidazo[1,2-a]pyrrolo[3,4-e]pyridin-1-one 
• 1603163-45-6 2-benzyl-4-(4-chlorophenyl)-9a-hydroxy-5-(4-methoxybenzoyl)-2,3,3a,4,6,7,8,9a-octahydro-1H-imidazo[1,2-a]pyrrolo[3,4-e]pyridin-1-one 

Relevant academic research and scientific papers

NHC-catalyzed [4 + 2] annulations of allenoates and 2,3-dioxopyrrolidine derivatives

A facile NHC-catalyzed [2 + 4] annulation of allenoates with 2,3-dioxypyrrolidine derivatives was discovered, which paved a new avenue for the construction of highly substituted pyranopyrrole with moderate to good yields, high atom economy and mild reaction conditions. This journal is

η6-Arene CH?O Interaction Directed Dynamic Kinetic Resolution – Asymmetric Transfer Hydrogenation (DKR-ATH) of α-Keto/enol-Lactams

A dynamic kinetic resolution – asymmetric transfer hydrogenation (DKR-ATH) methodology of α-keto/enol-lactams was developed. We also propose a possible catalytic mechanism evolving a transition state stabilized by η6-arene CH?O interaction. The efficient approach can be applied to a wide range of substrates including non-aryl ones which would be difficult to prepare by other asymmetric reduction methods. (Figure presented.).

Au(I)/(R)-BINOL-Ti(IV) concerted catalyzed asymmetric cascade cycloaddition reaction of arylalkynols

An efficient catalytic asymmetric cascade cycloaddition reaction of arylalkynols with dioxopyrrolidines was developed. This reaction was achieved using Au(I) and (R)-BINOL-Ti(IV) bimetallic catalysts and exclusively delivered a series of chiral oxo-bridged bicyclic benzooxacine compounds in up to 86% yield with 96% ee as well as >33:1 dr. Meanwhile, three new σ bonds and three new stereogenic centers were formed in a one-pot process.

Reactions of Sulfonium Salts with 2,3-Dioxopyrrolidine Derivatives: A Concise Synthesis of Spirocyclopropane

An efficient base-promoted spirocyclopropanation of 2,3-dioxopyrrolidine derivatives with sulfonium salts is described. This reaction enables a novel concise access to polysubstituted spirocyclopropane derivatives in good yields and with a trans/cis ratio of up to amp;gt;20:1 under mild conditions. amp;copy; Georg Thieme Verlag Stuttgart.