48059-97-8

Basic information

• Product Name: (E)-Oct-4-ene-1,8-dioic acid
• Synonyms: E-Oct-4-ene-1,8-dioicacid;4-Octenedioic acid,(4E)-
• CAS NO: 48059-97-8
• Molecular Formula: C₈H₁₂O₄
• Molecular Weight: 172.18
• Mol File: 48059-97-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 175-176 °C
• Boiling Point: 373.11 °C at 760 mmHg
• Flash Point: 193.63 °C
• Appearance: /
• Density: 1.2 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.501
• PKA: 4.27±0.10(Predicted)
• CAS DataBase Reference: (E)-Oct-4-ene-1,8-dioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-Oct-4-ene-1,8-dioic acid(48059-97-8)
• EPA Substance Registry System: (E)-Oct-4-ene-1,8-dioic acid(48059-97-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 48059-97-8(Hazardous Substances Data)

Usage

General Description

(E)-Oct-4-ene-1,8-dioic acid, also known as lepidic acid, is a chemical compound that belongs to the family of organic compounds known as unsaturated dicarboxylic acids. It is characterized by its molecular formula C8H10O4 and a structure containing a double bond between carbon atoms 4 and 5, and two carboxylic acid groups at positions 1 and 8. (E)-Oct-4-ene-1,8-dioic acid is a metabolite of certain fungi and is also produced by the degradation of linoleic acid. It has been found to exhibit antifungal and antibacterial properties, and has potential applications in the field of medicine and agriculture. Additionally, (E)-Oct-4-ene-1,8-dioic acid is also used as a chemical intermediate in the manufacturing of various products.

InChI:InChI=1/C8H12O4/c9-7(10)5-3-1-2-4-6-8(11)12/h1-2H,3-6H2,(H,9,10)(H,11,12)/b2-1+

Upstream product

• 6178-52-5 4-(phenylsulfonyl)butanoic acid 
• 71655-17-9 (E)-3-hexen-1,6-diol 
• 54432-95-0 di-tert-butyl (Z)-oct-4-enedioate 
• 591-80-0 pent-4-enoic acid 
• 63521-92-6 4-pentenoic anhydride 
• 19740-90-0 (Z)-9-oxabicyclo[6.1.0]non-4-ene 
• 5259-72-3 cyclo-octa-1,5-diene 
• 54432-94-9 Z-4-octenedioic acid dimethylester 
• 1552-12-1 1,5-cis,cis-cyclooctadiene 
• 199856-14-9 hex-3-yne-1,1,6,6-tetracarboxylic acid 
• 41613-54-1 hex-3-yne-1,1,6,6-tetracarboxylic acid tetraethyl ester 
• 65111-06-0 oct-4-ynedioic acid 
• 117468-07-2 rel-(1S,2S,5Z)-cyclooct-5-en-1,2-diol 
• 56506-08-2 (Z)-oct-4-ene-1,8-diol 

Relevant articles and documents

The effect of vicinal difluorination on the conformation and potency of histone deacetylase inhibitors

Histone deacetylase enzymes (HDACs) are potential targets for the treatment of cancer and other diseases, but it is challenging to design isoform selective agents. In this work, we created new analogs of two established but non selective HDAC inhibitors. We decorated the central linker chains of the molecules with specifically positioned fluorine atoms in order to control the molecular conformations. The fluorinated analogs were screened against a panel of 11 HDAC isoforms, and minor differences in isoform selectivity patterns were observed.

IMPROVED OLEFIN METATHESIS CATALYSTS

The present invention refers to novel ruthenium-based catalysts for olefin metathesis reactions, particularly to fast initiating catalysts having stereoselective properties. In olefin metathesis reactions, the disclosed catalysts provide a high catalytic activity combined with the capability to generate higher yields of the olefin metathesis product.

The synthesis of 12-membered macrocycles containing a C1-C8 alkene unit via ring-closing metathesis

Model cross and ring-closing metathesis strategies toward the C1-C8-linear carbon skeleton are presented. The introduction of a four-atom tether enables the formation of 12-membered rings in good-to-excellent yields and stereoselectivity. Furthermore, the study revealed that the cross-metathesis approach and the formation of medium ring sizes via ring-closing metathesis are much less favorable.