48068-25-3

Basic information

• Product Name: BOC-THR(ME)-OH
• Synonyms: BOC-THR(ME)-OH;BOC-O-METHYL-L-THREONINE;N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-L-THREONINE;(2S,3R)-2-(tert-butoxycarbonylamino)-3-methoxybutanoic acid;O-Methyl-L-threonine, N-BOC protected;N-Boc-O-Methyl-L-threonine;Boc-L-Thr(Me)-OH;(Tert-Butoxy)Carbonyl Thr(Me)-OH
• CAS NO: 48068-25-3
• Molecular Formula: C₁₀H₁₉NO₅
• Molecular Weight: 233.26
• Mol File: 48068-25-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 362.1±37.0 °C(Predicted)
• Appearance: /Solid
• Density: 1.123±0.06 g/cm3(Predicted)
• Refractive Index: 1.46
• Storage Temp.: 2-8°C
• PKA: 3.50±0.10(Predicted)
• CAS DataBase Reference: BOC-THR(ME)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-THR(ME)-OH(48068-25-3)
• EPA Substance Registry System: BOC-THR(ME)-OH(48068-25-3)

Safety Data

• Hazardous Substances Data: 48068-25-3(Hazardous Substances Data)

Usage

General Description

BOC-THR(ME)-OH is a chemical compound with the molecular formula C12H23NO4. It is a derivative of the amino acid threonine, with a BOC (tert-butyloxycarbonyl) protecting group on the amino group and a methyl (ME) group on the hydroxyl group. BOC-THR(ME)-OH is commonly used in peptide synthesis as a building block for creating peptides with specific sequences and structures. It is also used as a chiral auxiliary in organic synthesis and as a precursor for the preparation of various threonine derivatives. BOC-THR(ME)-OH is a white to off-white crystalline powder that is stable under normal storage conditions. It is important for the production of pharmaceutical and biotechnology products.

InChI:InChI=1/C10H19NO5/c1-6(15-5)7(8(12)13)11-9(14)16-10(2,3)4/h6-7H,1-5H3,(H,11,14)(H,12,13)/t6?,7-/m0/s1

Upstream product

• 4144-02-9 O-methyl-L-threonine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2592-18-9 Boc-Thr-OH 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 74-88-4 methyl iodide 

Downstream Products

• 1301706-86-4 N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-methyl-L-threonine 
• 4144-02-9 O-methyl-L-threonine 
• 537697-19-1 tert-butyl ((2R,3R)-1-hydroxy-3-methoxybutan-2-yl)carbamate 
• 1449473-81-7 4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate 
• 1449473-70-4 4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-1H-benzimidazol-5-yl}-3-chlorobenzonitrile formate 
• 1449476-01-0 tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate 
• 1422128-54-8 N²-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N,O-trimethyl-L-threoninamide 
• 1287206-16-9 ((1R,2R)-1-{[(4-bromophenyl)(trans-2-(pyrazin-2-yl)cyclopropanecarbonyl)amino]methyl}-2-methoxypropyl)carbamic acid tert-butyl ester 

Relevant articles and documents

BENZIIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AS SODIUM CHANNEL MODULATORS

The invention relates to benzimidazole and imidazopyridine derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new Nav1.8 modulators of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7. X and Y are as defined in the description. Nav1.8 modulators are potentially useful in the treatment of a wide range of disorders, particularly pain.

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β-Amino-α-hydroxycarboxylic acid derivatives represented by the following formula and salts thereof which are useful as human immunodeficiency virus (HIV) protease inhibitors: The compounds are effective for treating a patient suffering from AIDS and AIDS related diseases.