4808-64-4

Basic information

• Product Name: 2,6-DIMETHYL-4-NITROPYRIDINE-1-OXIDE
• Synonyms: 4-NITROLUTIDINE1-OXIDE;2,6-dimethyl-4-nitro-1-oxido-pyridine;4-NITRO 2,6 DIMETHYL PYRIDINE-N-OXIDE;4-Nitro-2,6-dimethylpyridine 1-oxide;2,6-Dimethyl-4-nitropyridin-1-ium-1-olate;2,6-dimethyl-4-nitro-1-oxidopyridin-1-ium
• CAS NO: 4808-64-4
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• Mol File: 4808-64-4.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 413.8 °C at 760 mmHg
• Flash Point: 204.1 °C
• Appearance: /
• Density: 1.3 g/cm³
• PKA: -0.99±0.10(Predicted)
• CAS DataBase Reference: 2,6-DIMETHYL-4-NITROPYRIDINE-1-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIMETHYL-4-NITROPYRIDINE-1-OXIDE(4808-64-4)
• EPA Substance Registry System: 2,6-DIMETHYL-4-NITROPYRIDINE-1-OXIDE(4808-64-4)

Safety Data

• Hazardous Substances Data: 4808-64-4(Hazardous Substances Data)

Usage

General Description

2,6-DIMETHYL-4-NITROPYRIDINE-1-OXIDE is a chemical compound with the molecular formula C7H8N2O3. It is a nitroso compound that is commonly used as a stable free radical in various chemical and biological applications. The compound is yellowish and crystalline in appearance, and it is soluble in organic solvents such as methanol and acetone. It is often utilized as a spin label for electron paramagnetic resonance (EPR) spectroscopy studies, as well as a photoinitiator in polymerization processes. Additionally, it has been investigated for potential use in pharmaceuticals and as a reagent in organic synthesis. However, it is important to handle this compound with caution, as it may present health and safety hazards.

InChI:InChI=1/C7H9N2O3/c1-5-3-7(9(11)12)4-6(2)8(5)10/h3-5H,1-2H3/q+1

Upstream product

• 6890-58-0 2,6-dimethylpyridine N-oxide hydrochloride 
• 54754-76-6 3-iodo-2,6-dimethyl-4-nitropyridine N-oxide 
• 1122-61-8 4-nitropyridine 
• 1124-33-0 4-nitraminopyridine N-oxide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 1073-23-0 2,6-lutidine N-oxide 
• 108-48-5 2,6-dimethylpyridine 

Downstream Products

• 3512-80-9 4-amino-2,6-lutidine 
• 3512-82-1 4-amino-2,6-dimethylpyridine 1-oxide 
• 697-92-7 2,6-dimethyl-4-chloropyridine N-oxide 
• 3512-75-2 4-chloro-2,6-lutidine 
• 90000-67-2 2,6-dimethyl-4-mercaptopyridine 
• 33259-24-4 3-bromo-4-amino-2,6-dimethylpyridine 
• 193690-76-5 2,6-dimethyl-4-methylaminopyridine 
• 193690-78-7 3-amino-2,6-dimethyl-4-(methylamino)pyridine 
• 193690-74-3 3,4,6-Trimethyl-3H-imidazo[4,5-c]pyridin-2-ylamine 
• 142590-65-6 Acetic acid 4-ethoxy-6-methyl-pyridin-2-ylmethyl ester 
• 98273-74-6 4-chloro-3,5-diiodo-2,6-dimethyl-pyridine 
• 98278-85-4 4-chloro-3,5-diiodo-pyridine-2,6-dicarboxylic acid 
• 20815-02-5 4-methoxy-2,6-dimethylpyridine 
• 1250445-93-2 4-nitro-2,6-diacetylpyridine bis(2,4,6-trimethylphenylimine) 

Relevant articles and documents

TGF-beta receptor inhibitor

The invention provides a compound shown as a formula (I) and a pharmaceutical composition thereof. The compound shown as the formula (I) of the present invention is useful as a TGF-beta receptor inhibitor, particularly a TGF beta RI inhibitor, for example, in the prevention or treatment of various TGF beta RI (ALK5) mediated related diseases.

Synthesis of 12-Membered Tetra-aza Macrocyclic Pyridinophanes Bearing Electron-Withdrawing Groups

The number of substituted pyridine pyridinophanes found in the literature is limited due to challenges associated with 12-membered macrocycle and modified pyridine synthesis. Most notably, the electrophilic character at the 4-position of pyridine in pyridinophanes presents a unique challenge for introducing electrophilic chemical groups. Likewise, of the few reported, most substituted pyridine pyridinophanes in the literature are limited to electron-donating functionalities. Herein, new synthetic strategies for four new macrocycles bearing the electron-withdrawing groups CN, Cl, NO2, and CF3 are introduced. Potentiometric titrations were used to determine the protonation constants of the new pyridinophanes. Further, the influence of such modifications on the chemical behavior is predicted by comparing the potentiometric results to previously reported systems. X-ray diffraction analysis of the 4-Cl substituted species and its Cu(II) complex are also described to demonstrate the metal binding nature of these ligands. DFT analysis is used to support the experimental findings through energy calculations and ESP maps. These new molecules serve as a foundation to access a range of new pyridinophane small molecules and applications in future work.

Preparation and purification method of toxic impurity DCAL of clopidol

The invention relates to a preparation and purification method of toxic impurity DCAL of clopidol and belongs to the technical field of preparation of standard medicine products. The preparation and purification method comprises the following steps: firstly carrying out chlorination reaction, i.e., dissolving a solvent and 2,6-dimethyl-4-aminopyridine; then slowly adding a chlorinating agent to carry out chlorination; after reaction is finished, carrying out neutralization and water washing, concentration and crystallization, filtering or direct neutralization and filtering on reaction liquidto obtain a crude DCAL product; purifying the crude DCAL product, adding a mixed solvent of ethanol and ethyl acetate into the crude DCAL product, stirring for dissolving, dripping petroleum ether toprecipitate solids, filtering, carrying out concentration, cooling and precipitation on filtrate, then filtering, and drying solids to obtain a pure DCAL product. The preparation and purification method has the beneficial effects that the reaction temperature is low, the reaction time is short, the side products in reaction are fewer, and the product is easily purified, so that convenience is brought for preparing impurity reference products of the veterinary-drug clopidol.