481-71-0Relevant academic research and scientific papers
Psoralenquinones as a novel class of proteasome inhibitors: Design, synthesis and biological evaluation
Marzaro, Giovanni,Gandin, Valentina,Marzano, Christine,Guiotto, Adriano,Chilin, Adriana
body text, p. 996 - 1000 (2012/01/06)
Proteasome subunit specificity: Psoralenquinones were identified as a novel class of nonpeptide proteasome inhibitors. Depending on the scaffold decoration, these compounds demonstrate interesting subunit specificity. Interactions with Thr1, Thr21 and Ser129 are critical for inhibition.
