(-)-3,4-Dihydro-3-hydroxy-7-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one, also known as (-)-rohitukine, is a naturally occurring chemical compound with significant anti-cancer properties. It is derived from the Indian tree Dysoxylum binectariferum and has demonstrated the ability to inhibit cell proliferation and induce apoptosis in cancer cells. As a microtubule-stabilizing agent, it interferes with the dynamics of microtubule assembly and disassembly, making it a promising candidate for further research and development in cancer treatment.
481-94-7
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Basic information
- Product Name: (-)-3,4-Dihydro-3-hydroxy-7-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
- Synonyms: (-)-3,4-Dihydro-3-hydroxy-7-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one;(-)-Mundulone;Mundulone
- CAS NO:481-94-7
- Molecular Formula: C26H26O6
- Molecular Weight: 434.48104
- EINECS: N/A
- Product Categories: N/A
- Mol File: 481-94-7.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 625.6°Cat760mmHg
- Flash Point: 213.4°C
- Appearance: /
- Density: 1.255g/cm3
- Vapor Pressure: 1.63E-16mmHg at 25°C
- Refractive Index: 1.599
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: (-)-3,4-Dihydro-3-hydroxy-7-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one(CAS DataBase Reference)
- NIST Chemistry Reference: (-)-3,4-Dihydro-3-hydroxy-7-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one(481-94-7)
- EPA Substance Registry System: (-)-3,4-Dihydro-3-hydroxy-7-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one(481-94-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 481-94-7(Hazardous Substances Data)
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481-94-7 Usage
Uses
Used in Pharmaceutical Industry:(-)-3,4-Dihydro-3-hydroxy-7-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one is used as a potential chemotherapeutic agent for its ability to inhibit cell proliferation and induce apoptosis in cancer cells. Its microtubule-stabilizing properties make it a valuable asset in the development of new cancer treatments.
Used in Cancer Research:
In the field of cancer research, (-)-3,4-Dihydro-3-hydroxy-7-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one serves as a subject of interest for preclinical studies. Its unique mechanism of action as a microtubule-stabilizing agent offers insights into the development of novel therapeutic strategies for various types of cancer.
Used in Drug Development:
(-)-3,4-Dihydro-3-hydroxy-7-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one is utilized in drug development for its potential as a chemotherapeutic agent. Its ability to target and stabilize microtubules offers a new approach to cancer treatment, warranting further investigation and optimization for clinical use.
Check Digit Verification of cas no
The CAS Registry Mumber 481-94-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 1 respectively; the second part has 2 digits, 9 and 4 respectively.Calculate Digit Verification of CAS Registry Number 481-94:
(5*4)+(4*8)+(3*1)+(2*9)+(1*4)=77
77 % 10 = 7
So 481-94-7 is a valid CAS Registry Number.
InChI:InChI=1/C26H26O6/c1-25(2)9-8-16-19(31-25)7-6-15(24(16)29-5)18-13-30-21-12-20-14(10-17(21)23(18)28)11-22(27)26(3,4)32-20/h6-10,12-13,22,27H,11H2,1-5H3
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(-)-3,4-Dihydro-3-hydroxy-7-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
