481054-91-5

Upstream product

• 131469-72-2 methyl 3-acetoxy-3-(4-chlorophenyl)-2-methylenepropanoate 
• 70-55-3 toluene-4-sulfonamide 
• 139413-75-5 methyl (2Z)-2-(bromomethyl)-3-(4-chlorophenyl)prop-2-enoate 
• 131469-67-5 methyl 2-[1-hydroxy-1-(4-chlorophenyl)methyl]acrylate 
• 357417-22-2 N-(4-chlorobenzylidene)-4-methylbenzenesulfonamide 

Downstream Products

• 1254218-41-1 methyl (E)-3-(4-chlorophenyl)-2-{[(prop-2-ynyl)tosylamino]methyl}prop-2-enoate 
• 379699-99-7 7-chloroquinoline-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Palladium-catalyzed domino cyclization (5-exo/3-exo), ring- expansion by palladium rearrangement, and aromatization: An expedient synthesis of 4-arylnicotinates from Morita-Baylis-Hillman adducts

Various 4-arylnicotinate derivatives were synthesized via a palladium-catalyzed cascade reaction of N-(2-bromoallyl)-N-cinnamyltosylamides in a one-pot procedure in good yields. The reaction involves a domino 5-exo/3-exo carbopalladation, ring-expansion b

Utility of allylic azides for the synthesis of fused triazoles and tetrazoles via intramolecular cycloaddition

The synthesis of a variety of annulated triazoles and tetrazoles from differently substituted allyl azides, afforded from the Baylis-Hillman adduct of acrylates, using intramolecular cycloaddition approach is described. Georg Thieme Verlag Stuttgart.

Highly Efficient aza-Baylis-Hillman Reaction of N-Tosylated Imines with MVK, Acrolein, and Phenyl Acrylate or α-Naphthyl Acrylate: Lewis Base Effects and A Convenient Method to Synthesize α,β-Unsaturated β-Amino Carbonyl Compounds

This paper describes several highly efficient aza-Baylis-Hillman reactions of N-tosylated imines with MVK, acrolein, and phenyl acrylate or α-naphthyl acrylate in the presence of a Lewis base. In most cases, the reaction can be completed within 1 h using

Synthesis of quinolines from the Baylis-Hillman acetates via the oxidative cyclization of sulfonamidyl radical as the key step

Ethyl 3-quinolinecarboxylates 5 were synthesized in good to moderate yields from the Baylis-Hillman acetates 1 via the oxidative cyclization reaction of the N-tosylamidyl radical, which was generated from the rearranged tosylamide derivatives 2 by iodoben