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Usage

Uses

Used in Pharmaceutical Industry:
1-methyl-4-phenyl-pyridine is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, particularly those targeting the central nervous system and other organ systems.
Used in Chemical Synthesis:
In the field of organic chemistry, 1-methyl-4-phenyl-pyridine serves as a versatile building block for the synthesis of a wide range of complex organic molecules. Its reactivity and structural features make it a valuable precursor for the creation of novel compounds with potential applications in various industries.
Used in Material Science:
The unique properties of 1-methyl-4-phenyl-pyridine also make it a candidate for the development of new materials with specific characteristics. It can be used in the synthesis of advanced materials for applications such as electronics, optics, and energy storage.
Used in Research and Development:
Due to its unique chemical structure and potential for various applications, 1-methyl-4-phenyl-pyridine is often utilized in research and development laboratories. It serves as a model compound for studying the properties and reactivity of pyridinium ions and their derivatives, contributing to the advancement of scientific knowledge in the field of chemistry.

InChI:InChI=1/C12H12N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-10H,1H3/q+1

Upstream product

• 939-23-1 p-phenylpyridine 
• 28289-54-5 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine 

Relevant academic research and scientific papers

The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase: Evidence for a novel mechanism of substrate inhibition

The N-methylation of 4-phenylpyridine produces the neurotoxin 1-methyl-4-phenylpyridinium ion (MPP+). We investigated the kinetics of 4-phenylpyridine N-methylation by nicotinamide N-methyltransferase (NNMT) and its effect upon 4-phenylpyridine toxicity i

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.

Chemical model studies on the monoamine oxidase-B catalyzed oxidation of 4-substituted 1-cyclopropyl-1,2,3,6-tetrahydropyridines

Two catalytic pathways have been proposed for the flavoenzyme monoamine oxidase B (MAO-B-one based on an initial single electron transfer (SET) step from the nitrogen lone pair and the second based on an initial α-carbon hydrogen atom transfer (HAT) step. The SET pathway is consistent with the mechanism based inactivation properties of various cyclopropylamines. The observation that MAO-B catalyzes the efficient oxidation of certain 1- cyclopropyl-4-substituted-1,2,3,6-tetrahydropyridines to the corresponding dihydropyridinium metabolites suggests that the catalytic pathway for these cyclic tertiary allylamines may not proceed via the putative SET generated aminyl radical cations. The present paper describes the chemical fate of a series of N-cyclopropyltetrahydropyridines examined under reaction conditions that model the SET and the HAT pathways. All of the test compounds were rapidly converted under HAT reaction conditions to their dihydropyridinium products. Although the test compounds also were oxidized rapidly under SET conditions, no evidence for dihydropyridinium product formation was observed. The products that were identified most likely were formed after cyclopropyl ring opening of the initially formed cyclopropylaminyl radical cation. The results are discussed in terms of the mechanism of MAO-B catalysis.