4815-97-8

Upstream product

• 2973-58-2 2-bromoisovanillin 
• 55171-60-3 2-bromo-3,4-dimethoxybenzylaldehyde 
• 621-59-0 isovanillin 

Downstream Products

• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 164991-68-8 decumbenine B 
• 1075694-36-8 (3,4-bis(methoxymethoxy)-2-(3-methylbut-2-en-1-yl)phenyl)methanol 
• 1372864-96-4 5-(2-bromo-3,4-dihydroxybenzylidene)-3-(2-ethylbutyl)thiazolidine-2,4-dione 
• 4815-98-9 O,O-Dibenzyl-2-brom-protocatechualdehyd 

Relevant academic research and scientific papers

SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

Imidazo ring PAR4 antagonist and medical applications thereof

The invention relates to an imidazo ring compound represented by formula (I) or formula (II), or a pharmaceutically acceptable salt or ester or solvate thereof. The compound disclosed by the inventioncan be used for preparing medicines for preventing or treating thromboembolic diseases.

Novel method for preparing decumbenine B

The invention provides a novel method for preparing a natural compound decumbenine B. The method comprises the following steps: (i) enabling a compound shown as a formula 4 and a compound shown as a formula 5 to be in contact under a condition suitable for carbon-carbon coupling, so as to generate a compound shown as a formula 3; (ii) carrying out cyclization on the compound shown as the formula 3and ammonium acetate under a suitable condition, so as to generate a compound 2; (iii) enabling the compound shown as the formula 2 and paraformaldehyde to react under the suitable condition, so as to generate the compound decumbenine B shown as a formula 1. (The formula 5, the formula 4, the formula 3, the formula 2 and the formula 1 are shown in the description.).

Intermediate of salvianolic acid A and preparation method of intermediate as well as preparation method of salvianolic acid A

The invention relates to an intermediate for preparing salvianolic acid A and a preparation method of the intermediate as well as a method for preparing the salvianolic acid A (shown as a formula I) by the intermediate. Specifically, the invention relates

Short synthesis of noscapine, bicuculline, egenine, capnoidine, and corytensine alkaloids through the addition of 1-siloxy-isobenzofurans to imines

A concise diastereotioselective strategy for the synthesis of noscapine, bicuculline, and egenine (1a-c), as well as capnoidine and corytensine (2a,b), was developed using diastereoselective addition of 1-siloxy-isobenzofurans 4a and 4b to iminium ion 5 in a one-pot approach. The synthesis features the use of imine 13 obtained through Bischler-Napieralsky reaction from amine 11. The addition of ionic liquids as addictives in the reactions afforded erythro configuration in major adduct compounds. The synthetic route can also be applied in the total synthesis of promising tubulin binding agent EM105 (3).

General Method for the Synthesis of Phthalaldehydic Acids and Phthalides from o-Bromobenzaldehydes via Ortho-Lithiated Aminoalkoxides

A general method for the synthesis of phthalaldehydic acids and phthalides, many of which are key intermediates in natural product synthesis, has been developed. o-Bromobenzaldehydes 1a-f were first protected in situ as α-morpholinoalkoxides by reaction with lithium morpholide.Treatment of the α-morpholinoalkoxides 3a-f with n-butyllithium (to exchange bromine with lithium) followed by sequential treatment with solid CO2 and dilute acid afforded the phthalaldehydic acids 6a-f, respectively.Reduction of 6a-f with NaBH4 in EtOH furnished the phthalides 7a-f, respectively, in nearly quantitative yields.Efficient methods for the synthesis of the o-bromobenzaldehydes 1a-d, which were not readily available, are also described.