48162-88-5Relevant academic research and scientific papers
A microwave-assisted highly practical chemoselective esterification and amidation of carboxylic acids
Pathak, Gunindra,Das, Diparjun,Rokhum, Lalthazuala
, p. 93729 - 93740 (2016/10/21)
The ubiquitousness of esters and amide functionalities makes their coupling reaction one of the most sought-after organic transformations. Herein, we have described an efficient microwave-assisted synthesis of esters and amides. Soluble triphenylphosphine, in conjugation with molecular iodine, gave the desired products without the requirement for a base/catalyst. In addition, a solid-phase synthetic route is incorporated for the said conversion, which has added advantages over solution-phase pathways, such as low moisture sensitivity, easy handling, isolation of the product by simple filtration, and reusability. In short, our method is simple, mild, green, and highly chemoselective in nature.
Diels-Alder Reactions of Furans with Itaconic Anhydride: Overcoming Unfavorable Thermodynamics
Pehere, Ashok D.,Xu, Shu,Thompson, Severin K.,Hillmyer, Marc A.,Hoye, Thomas R.
supporting information, p. 2584 - 2587 (2016/06/15)
Unfavorable thermodynamics often render furans reluctant to engage in high-yielding Diels-Alder (DA) cycloaddition reactions. Here, we report the highly efficient conversion of the biosourced reactants itaconic anhydride (IA) and furfuryl alcohol (FA) to
An efficient and regiospecific esterification of dioic acids using PTSA
Rama Devi,Rajaram
, p. 294 - 296 (2007/10/03)
Regiospecific mono alkyl esters of dioic acids have been obtained in excellent yield using PTSA as a catalyst. This method is mild and simpler than the previous methods.
The Design and Synthesis of New Triazolo-, Pyrazolo-, and Pyridazo-pyridazine Derivatives as Inhibitors of Angiotensin Converting Enzyme
Hassall, Cedric H.,Kroehn, Antonin,Moody, Cristopher J.,Thomas, W. Anthony
, p. 155 - 164 (2007/10/02)
Bicyclic mimetics of the antihypertensive, angiotensin converting enzyme (A.C.E.) inhibitor, captopril, have been designed with the aid of computer graphics.The synthesis and structure activity relationships of the three bicyclic systems tetrahydro
