481667-88-3Relevant academic research and scientific papers
Cobalt-catalyzed hydroarylation of alkynes through chelation-assisted C-H bond activation
Gao, Ke,Lee, Pin-Sheng,Fujita, Takeshi,Yoshikai, Naohiko
supporting information; experimental part, p. 12249 - 12251 (2010/11/18)
Ternary catalytic systems consisting of cobalt salts, phosphine ligands, and Grignard reagents promote addition of arylpyridines and imines to unactivated internal alkynes with high regio- and stereoselectivities. Deuterium-labeling experiments suggest that the reaction involves chelation-assisted oxidative addition of the aryl C-H bond to the cobalt center and insertion of the C-C triple bond into the Co-H bond, followed by reductive elimination of the resulting diorganocobalt species.
