481679-38-3Relevant academic research and scientific papers
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors
Lacombe, Patrick,Chauret, Nathalie,Claveau, David,Day, Stephen,Deschenes, Denis,Dube, Daniel,Gallant, Michel,Girard, Yves,Huang, Zheng,Laliberte, France,Levesque, Jean-Francois,Liu, Susana,Macdonald, Dwight,Mancini, Joseph A.,Masson, Paul,Nicholson, Donald W.,Nicoll-Griffith, Deborah A.,Salem, Myriam,Styhler, Angela,Young, Robert N.
scheme or table, p. 5266 - 5269 (2010/03/31)
Substituted 8-arylquinoline analogs bearing alkyl-linked side chain were identified as potent inhibitors of type 4 phophodiesterase. These compounds address the potential liabilities of the clinical candidate L-454560. The pharmacokinetic profile of the b
