481680-49-3Relevant academic research and scientific papers
Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor
Macdonald, Dwight,Mastracchio, Anthony,Perrier, Helene,Dube, Daniel,Gallant, Michel,Lacombe, Patrick,Deschenes, Denis,Roy, Bruno,Scheigetz, John,Bateman, Kevin,Li, Chun,Trimble, Laird A.,Day, Stephen,Chauret, Nathalie,Nicoll-Griffith, Deborah A.,Silva, Jose M.,Huang, Zheng,Laliberte, France,Liu, Susana,Ethier, Diane,Pon, Doug,Muise, Eric,Boulet, Louise,Chi, Chung Chan,Styhler, Angela,Charleson, Stella,Mancini, Joseph,Masson, Paul,Claveau, David,Nicholson, Donald,Turner, Mervyn,Young, Robert N.,Girard, Yves
, p. 5241 - 5246 (2007/10/03)
The discovery and SAR of a new series of substituted 8-arylquinoline PDE4 inhibitors are herein described. This work has led to the identification of several compounds with excellent in vitro and in vivo profiles, including a good therapeutic window of em
