48172-10-7

Basic information

• Product Name: (2S)-4-(1,3-Dioxoisoindolin-2-yl)-2-hydroxybutanoic acid
• Synonyms: 2-Hydroxy-4-phthalimidobutanoicacid;1,3-DIHYDRO-ALPHA-HYDROXY-1,3-DIOXO-2H-ISOINDOLE-2-BUTANOIC ACID;(2S)-4-(1,3-DIOXOISOINDOLIN-2-YL)-2-HYDROXYBUTANOIC ACID;2-HYDROXY-4-PHTHALIMIDOBUTYRIC ACID;4-PHTHALIMIDO-2-HYDROXY BUTYRIC ACID;(S)-(+)-ALPHA-HYDROXY-1,3-DIOXO-2-ISOINDOLINEBUTYRIC ACID;(S)-(+)-2-HYDROXY-4-PHTHALIMIDOBUTYRIC ACID;S-4-Phthalimido -2- hydroxybutyric acid
• CAS NO: 48172-10-7
• Molecular Formula: C₁₂H₁₁NO₅
• Molecular Weight: 249.22
• Product Categories: chiral;API intermediates;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides;Chiral Building Blocks;Heterocyclic Building Blocks;Indoles
• Mol File: 48172-10-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 157-159 °C(lit.)
• Boiling Point: 392.32°C (rough estimate)
• Flash Point: 264.1 °C
• Appearance: white to light yellow crystal powder
• Density: 1.3189 (rough estimate)
• Vapor Pressure: 2.37E-11mmHg at 25°C
• Refractive Index: 6 ° (C=1, MeOH)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: almost transparency in Methanol
• PKA: 3.67±0.10(Predicted)
• CAS DataBase Reference: (2S)-4-(1,3-Dioxoisoindolin-2-yl)-2-hydroxybutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-4-(1,3-Dioxoisoindolin-2-yl)-2-hydroxybutanoic acid(48172-10-7)
• EPA Substance Registry System: (2S)-4-(1,3-Dioxoisoindolin-2-yl)-2-hydroxybutanoic acid(48172-10-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 48172-10-7(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

(S)-(+)-2-Hydroxy-4-phthalimidobutyric Acid is used in preparation method of plazomicin key intermediate for simplifying operation and improving yield.

InChI:InChI=1/C12H11NO5/c14-9(12(17)18)5-6-13-10(15)7-3-1-2-4-8(7)11(13)16/h1-4,9,14H,5-6H2,(H,17,18)/p-1/t9-/m0/s1

Upstream product

• 85-44-9 phthalic anhydride 
• 3938-83-8 (S)-4-amino-2-hydroxybutanoic acid 

Downstream Products

• 1218922-63-4 (S)-benzyl 4-(1,3-dioxoisoindolin-2-yl)-2-hydroxybutanoate 

Relevant articles and documents

Synthesis method of amikacin intermediate

The invention belongs to the field of medicine synthesis, and particularly relates to a synthesis method of an amikacin intermediate. Phthaloyl chloride and 2-hydroxy-4-aminobutyric acid serve as theinitial raw materials, an acid-binding agent and a catalyst are added, the process of heating, washing, recrystallizing and the like is adopted, and finally the target amikacin intermediate product (2-hydroxy-4-phthaloyl iminobutyric acid) is obtained. In the synthesis method, the raw materials are easy to obtain, less reagents participate in the reaction, the steps are simple, operation is convenient, reaction conditions are mind, the product yield is high, and the method is suitable for industrial large-scale production.

DNA sequence selectivity of hairpin polyamide turn units

A class of hairpin polyamides linked by 3,4-diaminobutyric acid, resulting in a β-amine residue at the turn unit, showed improved binding affinities relative to their α-amino-γ-turn analogs for particular sequences. We incorporated β-amino-γ-turns in six-