481726-31-2 Usage
Description
1-methyl-2-chloromethyl-5-benzyloxypyridin-4(1H)-one hydrochloride is a chemical compound with the molecular formula C13H11ClN2O2HCl. It is a derivative of pyridinone, featuring a methyl group, a chloromethyl group, and a benzyloxy group attached to its structure. 1-methyl-2-chloromethyl-5-benzyloxypyridin-4(1H)-one hydrochloride is known for its potential applications in various fields, particularly in the pharmaceutical industry.
Uses
1. Used in Pharmaceutical Industry:
1-methyl-2-chloromethyl-5-benzyloxypyridin-4(1H)-one hydrochloride is used as a reagent for the synthesis of vanadyl-thiazolidinedione combination agents. These agents are utilized in the treatment of diabetes, specifically targeting the improvement of insulin sensitivity and glucose metabolism in patients.
2. Used in Synthesis of Vanadyl-Thiazolidinedione Combination Agents:
As a key reagent, 1-methyl-2-chloromethyl-5-benzyloxypyridin-4(1H)-one hydrochloride plays a crucial role in the development of vanadyl-thiazolidinedione combination agents. These agents are designed to address the challenges associated with diabetes management by combining the benefits of thiazolidinedione, which enhances insulin sensitivity, and vanadium, which mimics the action of insulin.
Check Digit Verification of cas no
The CAS Registry Mumber 481726-31-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,8,1,7,2 and 6 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 481726-31:
(8*4)+(7*8)+(6*1)+(5*7)+(4*2)+(3*6)+(2*3)+(1*1)=162
162 % 10 = 2
So 481726-31-2 is a valid CAS Registry Number.
481726-31-2Relevant articles and documents
Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors
Ma, Yongmin,Luo, Wei,Quinn, Peter J.,Liu, Zudong,Hider, Robert C.
, p. 6349 - 6362 (2004)
The synthesis of a range of novel 3-hydroxypyridin-4-ones and 3-hydroxypyran-4-ones linked with different coumarin substituents is described. These compounds have been developed in order to provide a series of molecular probes for the quantification of intracellular labile iron pools. An evaluation of the effect of iron(III) on fluorescence intensity was undertaken. Chelation of iron(III) causes quenching of fluorescence. The relationship between iron(III) concentration and the extent of fluorescence quenching indicates that the metal is chelated in a complex with a metal-to-ligand stoichiometry of 1:3. The fluorescence of hydroxypyridinone compounds was found to be more efficiently quenched by iron(III) than were the hydroxypyranones. The metal-to-ligand stoichiometry at which maximum quenching is observed was found to depend on the site at which coumarin is attached. The efficiency of fluorescence quenching by iron(III) is markedly influenced by solvent polarity and pH. The permeability of two representative fluorescent chelators across human erythrocyte ghost membranes was investigated. The rate of permeability for a series of probes was found to be related to the corresponding ClogP values.
