482-25-7

Basic information

• Product Name: BYAKANGELICIN
• Synonyms: Biacangelicin;Bjacangelicin;Bjakangelicin;Byankagelicine;9-[(2R)-2,3-dihydroxy-3-methyl-butoxy]-4-methoxy-furo[3,2-g]chromen-7-one;9-[(2R)-2,3-dihydroxy-3-methylbutoxy]-4-methoxyfuro[3,2-g]chromen-7-one;BYAKANGELICIN (P);5-Methoxy-8-(2,3-dihydroxy-3-methylbutoxy)psoralene
• CAS NO: 482-25-7
• Molecular Formula: C₁₇H₁₈O₇
• Molecular Weight: 334.32062
• Mol File: 482-25-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 123-124℃
• Boiling Point: 571.5°Cat760mmHg
• Flash Point: 299.4°C
• Appearance: /
• Density: 1.373
• Vapor Pressure: 6.69E-14mmHg at 25°C
• Refractive Index: 1.613
• Storage Temp.: ?20°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.67±0.20(Predicted)
• CAS DataBase Reference: BYAKANGELICIN(CAS DataBase Reference)
• NIST Chemistry Reference: BYAKANGELICIN(482-25-7)
• EPA Substance Registry System: BYAKANGELICIN(482-25-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 482-25-7(Hazardous Substances Data)

Usage

Uses

(+)-Byakangelicin is an effective inhibitor of sex hormones and affects the catabolism of endogenous hormones. It directly affects the cytochrome P450 isoform (CY) P3A4 in human hepatocytes. Also, an inhibitor of aldose reductase and used in the treatment of diabetic cataract.

InChI:InChI=1/C17H18O7/c1-17(2,20)11(18)8-23-16-14-10(6-7-22-14)13(21-3)9-4-5-12(19)24-15(9)16/h4-7,11,18,20H,8H2,1-3H3

Downstream Products

• 61046-59-1 (+/-)-byakangelicol 
• 35214-81-4 4-methoxy-9-(3-methyl-2-oxo-butoxy)-furo[3,2-g]chromen-7-one 

Relevant articles and documents

Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-γ ligand-binding activity

A phytochemical investigation of the root of Angelica dahurica led to the isolation of benzofuran and coumarin derivatives. This is the first report of the isolation and identification of three furanocoumarin sulfates from A. dahurica root. The structures of a total of twelve undescribed compounds were determined by extensive spectroscopic analysis, including 2D NMR data, hydrolysis, and solvolysis, followed by either physicochemical and spectroscopic data or X-ray crystallographic analysis. The isolated compounds were evaluated for their PPAR-γ ligand-binding activity, and six compounds showed significant PPAR-γ ligand-binding activity. In particular, the undescribed benzofuran derivative, 3-[6,7-furano-9-hydroxy-4-(2″,3″-dihydroxy-3″-methylbutyloxy)]-phenyl propionic acid, exhibited the most potent PPAR-γ ligand-binding activity and accumulated intracellular lipid in 3T3-L1 cells.