482-27-9 Usage
Uses
Used in Pharmaceutical Industry:
ISOPIMPINELLIN is used as an antiviral agent for its ability to inhibit the replication of certain viruses, particularly the Human Immunodeficiency Virus (HIV). Its photoactive properties allow it to interfere with the viral life cycle, making it a potential candidate for the development of new antiviral drugs.
Used in Anticancer Applications:
In the field of oncology, ISOPIMPINELLIN is used as an antineo-plastic agent. It has shown potential in inhibiting the growth of cancer cells and has been investigated for its use in photodynamic therapy, a treatment that uses light to activate a drug that kills cancer cells.
Used in Agricultural Industry:
ISOPIMPINELLIN is used as an antifungal agent to protect crops from fungal infections. Its natural occurrence in plants suggests that it may have a role in the plants' defense mechanisms against fungal pathogens.
Used in Insect Control:
ISOPIMPINELLIN is used as an insect antifeedant, deterring insects from feeding on treated plants. This property can be harnessed in the development of natural pest control methods, reducing the reliance on synthetic chemical pesticides.
Hazard
A poison by ingestion.
Contact allergens
Psoralens are natural photoactivable compounds in plants and can cause phototoxic contact dermatitis. For example, Cachrys libanotis L., Apiaceae-Umbelliferae family, contains 5,8-dimethoxypsoralen.
Check Digit Verification of cas no
The CAS Registry Mumber 482-27-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 482-27:
(5*4)+(4*8)+(3*2)+(2*2)+(1*7)=69
69 % 10 = 9
So 482-27-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H10O5/c1-15-10-7-3-4-9(14)18-12(7)13(16-2)11-8(10)5-6-17-11/h3-6H,1-2H3
482-27-9Relevant academic research and scientific papers
Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor
Marumoto, Shinsuke,Miyazawa, Mitsuo
supporting information; experimental part, p. 784 - 788 (2012/03/22)
The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins inhibited BACE1 activity, but simple coumarins and pyranocoumarins did not affect. The most potent inhibitor was 5-geranyloxy-8-methoxypsoralen (31), which has an IC50 value of 9.9 μM. Other furanocoumarin derivatives, for example, 8-geranyloxy-5- methoxypsoralen (35), 8-geranyloxypsoralen (24), and bergamottin (18) inhibited BACE1 activity, with the IC50 values 25.0 μM. Analyses of the inhibition mechanism by Dixon plots and Cornish-Bowden plots showed that compounds 18, 31 and 35 were mixed-type inhibitor. The kinetics of inhibition of BACE1 by coumarins 24 was non-competitive inhibitors.
Palatable solid pesticidal compositions of ethylene and vinyl acetate copolymer
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, (2008/06/13)
The invention comprises compositions in solid form of ethylene/vinyl acetate copolymer with an effective amount of bioactive agent, a protein/carbohydrate-lipid source, 0 to 20% of an edible oil and optionally an attractant, dye, preservative, adversive agent and biomarker and the use, thereof, to control pests.
