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Relevant academic research and scientific papers

Termination of the structural confusion between plipastatin A1 and fengycin IX

Plipastatin A1 and fengycin IX were experimentally proven to be identical compounds, while these had been considered as diastereomers due to the permutation of the enantiomeric pair of Tyr in most papers. The 1H NMR spectrum changed to become quite similar to that of plipastatin A1, when the sample which provided resembled spectrum of fengycin IX was treated with KOAc followed by LH-20 gel filtration. Our structural investigations disclosed that the structures of these molecules should be settled into that of plipastatin A1 by Umezawa (l-Tyr4 and d-Tyr10).

Chiral separation of enantiomers of amino acid derivatives by HPLC on vancomycin and teicoplanin chiral stationary phases

The chiral separation of α-amino acids by liquid chromatography using macrocyclic antibiotic bonded stationary phases were studied. Teicoplanin and vancomycin bonded stationary phases have been used to separate enantiomers of dansyl amino acids in the reversed - phase high performance liquid chromatography mode. By comparison of chromatographic parameters obtained by use of both chiral stationary phases it the mechanism of chiral separation could be suggested. The better separation - greater value of R(j,i) of enantiomers - was achieved by the teicoplanin column.

Marine natural products. XXV. Biologically active tridecapeptide lactones from the Okinawan marine sponge Theonella swinhoei (theonellidae). Structure of theonellapeptolide Id

Theonellapeptolide Id (1), a tridecapeptide lactone, was isolated from the Okinawan marine sponge Theonella swinhoei and the structure 1 was determined. A new HPLC analysis method for analyzing the amino acid composition of 1 containing N-methyl amino acids was devised.