482377-80-0Relevant academic research and scientific papers
Convenient synthesis and isolation of conformationally rigid glutamic acid analogues
Greenfield,Butera
, p. 3939 - 3947 (2004)
A convenient synthetic methodology for the synthesis of highly conformationally restricted tricyclic aminodicarboxylic acids bridged analogues of glutamic acid, is presented. The process can be used for preparation of the novel glutamate analogues.
Synthesis of the four 3-aminotricyclo [2.2.1.0(2,6)] heptane-1,3- dicarboxylic acid isomers
Baudy, Reinhardt B.,Sze, Jean Y.,Butera, John A.
, p. 3949 - 3954 (2004)
A process to prepare the four stereoisomers of the tricyclic 3-aminotricyclo[2.2.1.0(2,6)] heptane-1,3-dicarboxylic acid, a potent selective inhibitor of the EAAT2 transporter, is described.
Bridged tricyclid analogs of 2-(carboxycyclopropyl)glycine
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, (2008/06/13)
This invention provides processes for preparing a group of novel bridged tricyclic compounds having the formula: wherein X is (CH2)n, O, S, SO, SO2 or CR1R2; n is 1 or 2; and R1 and R2 are, independently, hydrogen, halogen, hydroxy, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, or R1 and R2, taken together with the carbon to which they are attached, form cycloalkyl of three to six carbon atoms, an alkylidene of up to six carbon atoms or a carbonyl.
Stereoisomers of 3-aminotricyclo[2.2.1.0(2.6)]heptane-1,3-dicarboxylic acid
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, (2008/06/13)
This invention provides a process for the preparation of all four stereoisomers of formula I or a pharmaceutically acceptable salt thereof which may be represented by the following structures:
