482577-59-3

Basic information

• Product Name: L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE
• Synonyms: L-Valine,N-[(2'-cyano[1,1'-biphenyl]-4-yl)Methyl]-, Methyl ester, hydrochloride (1:1);N-[(2’-cyanobiphenyl-4-yl)methyl]-l-Valine methyl ester hydrochloride (CMVEH);N-(2'-Cyanobiphenyl-4-ylmethyl) L-valine methyl ester monohydrochloride, 95%;-3-methylbutanoate hydrochloride;-Methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl);L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE;N-[(2'-cyano[1,1'biphenyl]-4-yl)methyl]-methyl ester L-valine monohydrochloride;N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valinemethyl ester hydrochloride
• CAS NO: 482577-59-3
• Molecular Formula: C₂₀H₂₂N₂O₂*ClH
• Molecular Weight: 358.86
• EINECS: 1308068-626-2
• Mol File: 482577-59-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 186℃
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE(482577-59-3)
• EPA Substance Registry System: L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE(482577-59-3)

Safety Data

• Hazardous Substances Data: 482577-59-3(Hazardous Substances Data)

Usage

Uses

Hydrochloride Salt of N-[(2''-Cyano[1,1''-biphenyl]-4-yl)methyl]-L-valine Methyl Ester is an intermediate in the preparation of angiotensin II type 1 receptor antagonists.

Upstream product

• 6306-52-1 L-valine methylester hydrochloride 
• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 

Downstream Products

• 137863-17-3 methyl N-((2’-(1H-tetrazol-5-yl)-[1,1’-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valinate 
• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 
• 676129-92-3 desvaleroyl valsartan 
• 137862-53-4 valsartan 
• 137863-90-2 methyl 2-(N-((2'-cyanobiphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate 
• 137863-89-9 N-[(2'-cyanobiphenyl-4-yl)-methyl]-(L)-valine methyl ester 

Relevant articles and documents

A method for preparing methyl valsartan

The invention provides a preparation method of valsartan. The preparation method has the technical effects that amide methyl ester and sodium azide are used as raw materials and are catalyzed by amine salt to carry out tetrazole formation reaction; side effects are minimized by controlling the reaction course; main products are furthest generated; unreacted raw materials are recycled and reused; the yield in the preparation method is increased by more than 10% relative to the yields in existing processes; compared with the existing processes, the method has the effect that plenty of high-toxicity wastewater is no longer generated, and is easy to be widely popularized industrially.