483-60-3 Usage
Uses
Used in Pharmaceutical Industry:
6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methylhex-4-enoic acid is used as a potential antibiotic agent for its ability to combat various diseases and infections. Its unique structure and properties make it a valuable compound for researchers and chemists in the development of new and improved drugs.
Used in Antibiotic Development:
6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methylhex-4-enoic acid is used as a key component in the synthesis and modification of new antibiotics. Its complex structure allows for the exploration of various chemical modifications to enhance its effectiveness and target specific pathogens.
Check Digit Verification of cas no
The CAS Registry Mumber 483-60-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 483-60:
(5*4)+(4*8)+(3*3)+(2*6)+(1*0)=73
73 % 10 = 3
So 483-60-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
483-60-3Relevant academic research and scientific papers
Biotransformations of imbricatolic acid by Aspergillus niger and Rhizopus nigricans cultures
Schmeda-Hirschmann, Guillermo,Aranda, Carlos,Kurina, Marcela,Rodriguez, Jaime A.,Theoduloz, Cristina
, p. 1092 - 1100 (2008/02/11)
Microbial transformation of imbricatolic acid (1) by Aspergillus niger afforded 1α-hydroxyimbricatolic acid (2), while transformation with Rhizopus nigricans yielded 15-hydroxy-8,17-epoxylabdan-19-oic acid (3). When the diterpene 1 was added to a Cunninghamella echinulata culture, the main products were the microbial metabolites mycophenolic acid (4) and its 3-hydroxy derivative 5. All the structures were elucidated by spectroscopic methods. The cytotoxicity of these compounds towards human lung fibroblasts and AGS cells was assessed. While 4 and 5 showed low cytotoxicity, with IC50 values > 1000 μM against AGS cells and fibroblasts, 1α-hydroxyimbricatolic acid (2) presented moderate toxicity towards these targets, with IC50 values of 307 and 631 μM, respectively. The structure of 2 is presented for the first time.
