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Toddalolactone is a prenylated coumarin found in Toddalia aculeata Pers. (Rutaceae), a plant that also contains Berberine. It forms colorless crystals from CHCl3 and is characterized by its various derivatives such as hydrochloride monohydrate, nitrate, and picrate. Toddalolactone is known for its presence of two methoxyl groups and a methylimino group, and it exhibits natural phosphodiesterase-4 inhibitory properties.

483-90-9

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483-90-9 Usage

Uses

Used in Pharmaceutical Industry:
Toddalolactone is used as an antiplasmodial agent for its ability to inhibit the growth of Plasmodium parasites, which are responsible for malaria. This application is particularly important in the development of new treatments for drug-resistant strains of malaria.
Used in Agricultural Industry:
Toddalolactone is used as a larvicidal agent to control the population of insects, particularly mosquitoes, which are vectors for various diseases. Its larvicidal properties make it a valuable tool in integrated pest management strategies to reduce the reliance on chemical insecticides and minimize environmental impact.
Used in Research and Development:
Toddalolactone is used as a natural phosphodiesterase-4 inhibitor in the field of research and development. Its inhibitory effects on phosphodiesterase-4 make it a potential candidate for the development of new drugs targeting various diseases and conditions related to this enzyme's activity.

References

Dey, Pillay., Arch. Pharm., 271,477 (1933)Dey et al., Ind. J. Med. Res., 22,765 (1935) Lobstein, Hesse., Bull. Sci. Pharmacol., 38, 157 (1931)

Check Digit Verification of cas no

The CAS Registry Mumber 483-90-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 483-90:
(5*4)+(4*8)+(3*3)+(2*9)+(1*0)=79
79 % 10 = 9
So 483-90-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H20O6/c1-16(2,19)13(17)7-10-11(20-3)8-12-9(15(10)21-4)5-6-14(18)22-12/h5-6,8,13,17,19H,7H2,1-4H3/t13-/m1/s1

483-90-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one

1.2 Other means of identification

Product number -
Other names (+)-toddalolactone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:483-90-9 SDS

483-90-9Upstream product

483-90-9Downstream Products

483-90-9Relevant academic research and scientific papers

The Absolute Stereochemistries of (+)-Toddalolactone and its Related Chiral Coumarins from Toddalia asiatica (L.) Lam. (T. aculeata Pers.) and their Optical Purities

Ishii, Hisashi,Kobayashi, Jun-Ichi,Sakurada, Eri,Ishikawa, Tsutomu

, p. 1681 - 1684 (1992)

The absolute stereochemistries of (+)-toddalolactone (+)-1 and its related chiral coumarins (+)-toddanol (+)-2, (+)-6-(2-hydroxy-3-methoxy-3-methylbutyl)-5,7-dimethoxycoumarin (+)-3, (+)-6-(3-chloro-2-hydroxy-3-methylbutyl)-5,7-dimethoxycoumarin (+)-4 an

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