4830-84-6Relevant academic research and scientific papers
Spectroscopic, density functional theory, nonlinear optical properties and in vitro biological studies of Co(II), Ni(II), and Cu(II) complexes of hydrazide Schiff base derivatives
Ramadan, Ramadan M.,El-Medani, Samir M.,Makhlouf, Abdelmoneim,Moustafa, Hussein,Afifi, Manal A.,Haukka, Matti,Abdel Aziz, Ayman
, (2021)
Complexes of three molecularly designed phenylacetohydrazide Schiff base derivatives—N′-(2-hydroxybenzylidene)-2-phenylacetohydrazid (HL1), N-(1-(2-hydroxyphenyl)ethylidene)-2-phenylacetohydrazide (HL2), and N′-((1-hydroxynaphthalen-2-yl)methylene)-2-phenylacetohydrazide (HL3)—with some bivalent metal ions were synthesized and investigated by several spectroscopic and analytical techniques. The crystal structure of HL1 ligand has been solved by conventional X-ray diffraction technique. Molecular geometries of HL1 and the studied complexes were investigated using the DFT-B3LYP/GENECP level of theory. Quantum and non-quantum global reactivity descriptors as well as the nonlinear optical properties were calculated. Biological parameters such as antimicrobial and antioxidant activities, fluorescence quenching studies, and viscosity measurements of the complexes were carried out. Molecular docking studies of HL1 and complexes using Molecular Operating Environment (MOE) software are reported. The different biological studies and the molecular docking were correlated to each other. The biological studies supported that the complexes can bind to DNA via intercalative mode and showed a various DNA binding potency.
Influence of synthesis conditions on complexation of Cu (II) with O,N,O tridentate hydrazone ligand. X-ray diffraction and spectroscopic investigations
Repich,Orysyk,Orysyk,Zborovskii, Yu.L.,Melnyk,Trachevskyi,Pekhnyo,Vovk
, p. 222 - 232 (2017)
Four novel Cu2+ coordination compounds with a (E)-N′-(2-hydroxybenzylidene)-2-phenylacetohydrazide (HBPAH, H2L) have been synthesized and characterized by single crystal X-ray diffraction method, IR, UV–Vis and EPR spectroscopy. In a
Design, synthesis and in vitro antimalarial activity of an acylhydrazone library
Melnyk, Patricia,Leroux, Virginie,Sergheraert, Christian,Grellier, Philippe
, p. 31 - 35 (2007/10/03)
A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the
