483279-35-2Relevant academic research and scientific papers
Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin.
Bhattacharya, Gautam,Salem, Manar M,Werbovetz, Karl A
, p. 2395 - 2398 (2007/10/03)
Novel dinitroaniline sulfonamides based on the herbicide oryzalin 3 were synthesized and evaluated for activity against the parasitic protozoan Leishmania donovani and against leishmanial tubulin, the putative antiparasitic target of oryzalin. A subset of these compounds possess more activity against both Leishmania and the target protein in vitro. Compound 20 displays improved potency against leishmanial tubulin and is 13.4-fold more active against L. donovani axenic amastigotes than oryzalin.
