483366-12-7

Basic information

• Product Name: (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
• Synonyms: (2S,4R)-tert-Butyl 2-cyano-4-hydroxypyrrolidine-1-carboxylate;-tert-Butyl 2-cyano-4-hydroxypyrrolidine-1-carboxylate;(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine;1-Pyrrolidinecarboxylic acid, 2-cyano-4-hydroxy-, 1,1-dimethylethyl ester, (2S,4R)-
• CAS NO: 483366-12-7
• Molecular Formula: C₁₀H₁₆N₂O₃
• Molecular Weight: 212.24564
• Mol File: 483366-12-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 361.4 °C at 760 mmHg
• Flash Point: 172.4 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 1.11E-06mmHg at 25°C
• Refractive Index: 1.511
• Storage Temp.: 2-8°C
• PKA: 13.90±0.40(Predicted)
• CAS DataBase Reference: (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine(483366-12-7)
• EPA Substance Registry System: (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine(483366-12-7)

Safety Data

• Hazardous Substances Data: 483366-12-7(Hazardous Substances Data)

Usage

General Description

(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine is a chemical compound with the molecular formula C9H15NO3. It is a derivative of pyrrolidine and contains a Boc (tert-butoxycarbonyl) protecting group, a cyano group, and a hydroxy group. (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine is primarily used as a building block in organic synthesis and medicinal chemistry. It can be used as a chiral building block in the synthesis of pharmaceutical compounds and complex organic molecules. The stereochemistry and functional groups present in (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine make it a versatile and valuable compound in chemical research and drug development.

InChI:InChI=1/C10H16N2O3/c1-10(2,3)15-9(14)12-6-8(13)4-7(12)5-11/h7-8,13H,4,6H2,1-3H3/t7-,8+/m0/s1

Upstream product

• 109384-24-9 tert-butyl (2S,4R)-2-(aminocarbonyl)-4-hydroxypyrrolidine-1-carboxylate 
• 22821-76-7 4-(methylsulfonyl)benzonitrile 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 946610-68-0 (4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 172876-96-9 3-oxo-1λ³-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile 
• 1000616-48-7 tert-butyl (2S,4R)-2-cyano-4-benzoyloxypyrrolidine-1-carboxylate 

Relevant articles and documents

Decarboxylative Cyanation of Aliphatic Carboxylic Acids via Visible-Light Flavin Photocatalysis

An operationally simple method is disclosed for the decarboxylative cyanation of aliphatic carboxylic acids at room temperature. Riboflavin tetraacetate, which is an inexpensive organic photocatalyst, promotes the oxidation of carboxylic acids upon visible-light activation. After decarboxylation, the generated radicals are trapped by TsCN, yielding the desired nitriles without any further additive, in a redox-neutral process. Importantly, this protocol can be adapted to flow conditions.

DICYCLOAZAALKANE DERIVATES, PREPARATION PROCESSES AND MEDICAL USES THEREOF

Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification.

NEW COMPOUNDS

The present invention relates to the novel compounds of the general formula (I) possessing DPP-IV inhibitory activity. These compounds contain tropane building blocks.