4836-52-6

Basic information

• Product Name: (2S)-2-amino-3-(3H-imidazol-4-yl)propan-1-ol
• Synonyms: (2S)-2-amino-3-(3H-imidazol-4-yl)propan-1-ol;(2S)-2-Amino-3-(1H-imidazole-4-yl)-1-propanol;(S)-β-Amino-1H-imidazole-4-propan-1-ol;1H-IMidazole-4-propanol, b-aMino-, (bS)-;(betaS)-beta-Amino-1H-imidazole-5-propanol;(S)-Histidinol;(2S)-2-amino-3-(1H-imidazol-5-yl)propan-1-ol
• CAS NO: 4836-52-6
• Molecular Formula: C₆H₁₁N₃O
• Molecular Weight: 141.171
• Mol File: 4836-52-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 197-199.5℃
• Boiling Point: 455.5°Cat760mmHg
• Flash Point: 229.3°C
• Appearance: /
• Density: 1.261g/cm³
• Vapor Pressure: 4.34E-09mmHg at 25°C
• Refractive Index: 1.594
• PKA: 12.63±0.10(Predicted)
• CAS DataBase Reference: (2S)-2-amino-3-(3H-imidazol-4-yl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-amino-3-(3H-imidazol-4-yl)propan-1-ol(4836-52-6)
• EPA Substance Registry System: (2S)-2-amino-3-(3H-imidazol-4-yl)propan-1-ol(4836-52-6)

Safety Data

• Hazardous Substances Data: 4836-52-6(Hazardous Substances Data)

Usage

Definition

ChEBI: An amino alcohol that is propanol substituted by 1H-imidazol-4-yl group at position 3 and an amino group at position 2 (the 2S stereoisomer).

InChI:InChI=1/C6H11N3O/c7-5(3-10)1-6-2-8-4-9-6/h2,4-5,10H,1,3,7H2,(H,8,9)/t5-/m0/s1

Upstream product

• 194797-41-6 N-[(S)-1-hydroxymethyl-2-(1⁽³⁾H-imidazol-4-yl)-ethyl]-benzamide 
• 1499-46-3 L-Histidine methyl ester 
• 25679-93-0 L-histidinol 1-phosphate 
• 223910-41-6 2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanol ditrityl-L-histidinol 
• 3005-62-7 (S)-(-)-methyl 2-benzamido-3-(4,5-dihydro-1H-imidazol-5-yl)propanoate 
• 645-35-2 L-histidine monohydrochloride 

Downstream Products

• 75614-85-6 (S)-(+)-4-(2-amino-3-chloropropyl)-imidazole dihydrochloride 
• 80714-55-2 S-(+)-α-Chloromethylhistamine 
• 1333227-24-9 CH₂O₂*C₁₉H₂₆N₄O₄ 
• 75614-87-8 (R)-2-(1H-Imidazol-4-yl)-1-methyl-ethylamine 
• 79990-23-1 N-formyl-D-alanyl-N(Im)-tosyl-O-acetyl-L-histidinol 

Relevant articles and documents

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Hit to lead studies on (hetero)arylpyrimidines-Agonists of the canonical Wnt-β-catenin cellular messaging system

A series of (hetero)arylpyrimidines agonists of the Wnt-β-catenin cellular messaging system have been prepared. These compounds show activity in U2OS cells transfected with Wnt-3a, TCF-luciferase, Dkk-1 and tk-Renilla. Selected compounds show minimal GSK-3β inhibition indicating that the Wnt-β-catenin agonism activity most likely comes from interaction at Wnt-3a/Dkk-1. Two examples 1 and 25 show in vivo osteogenic activity in a mouse calvaria model. One example 1 is shown to activate non-phosphorylated β-catenin formation in bone.