4836-98-0

Usage

Uses

Used in Pharmaceutical Development:
1,2,3,4-Tetrahydroisoquinolin-2-amine is used as a building block in the pharmaceutical industry for the synthesis of various biologically active compounds. Its unique structure allows for the creation of molecules with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic chemistry, 1,2,3,4-Tetrahydroisoquinolin-2-amine is utilized as a key intermediate in the synthesis of complex organic molecules, contributing to the development of new chemical entities with specific properties.
Used in Medicinal Chemistry Research:
1,2,3,4-Tetrahydroisoquinolin-2-amine is employed in medicinal chemistry research to explore its biological activities and to understand its potential as a precursor for synthesizing molecules with therapeutic relevance.
Used in the Study of Chemical Reactions and Mechanisms:
1,2,3,4-Tetrahydroisoquinolin-2-amine is also used in academic and research settings to investigate chemical reactions and mechanisms, providing insights into organic chemistry that can be applied to the development of new synthetic pathways and methodologies.

InChI:InChI=1/C9H12N2/c10-11-6-5-8-3-1-2-4-9(8)7-11/h1-4H,5-7,10H2

Upstream product

• 10308-72-2 2-nitro-1,2,3,4-tetrahydro-isoquinoline 
• 14099-81-1 1,2,3,4-tetrahydroisoquinoline 
• 17721-96-9 2-nitroso-1,2,3,4-tetrahydroisoquinoline 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 4836-54-8 phenyl-acetone-(3,4-dihydro-1H-[2]isoquinolylimine) 
• 52320-36-2 5-methyl-isoxazole-3-carboxylic acid 4-[(3,4-dihydro-1H-isoquinolin-2-ylcarbamoyl)-sulfamoyl]-phenethylamide 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 80545-09-1 N-(3,4-Dihydro-1H-isoquinolin-2-yl)-guanidine; compound with nitric acid 
• 61001-37-4 ethyl 2-phenyl-5,6-dihydropyrazolo[5,1-a]isoquinoline-1-carboxylate 

Relevant academic research and scientific papers

Discovery and structural analyses of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs

Optimization of a new series of S-adenosyl-l-homocysteine hydrolase (AdoHcyase) inhibitors based on non-adenosine analogs led to very potent compounds 14n, 18a, and 18b with IC50 values of 13 ± 3, 5.0 ± 2.0, and 8.5 ± 3.1 nM, respectively. An X-ray crystal structure of AdoHcyase with NAD+ and 18a showed a novel open form co-crystal structure. 18a in the co-crystals formed intramolecular eight membered ring hydrogen bond formations. A single crystal X-ray structure of 14n also showed an intramolecular eight-membered ring hydrogen bond interaction.

Carbazates as potent inhibitors of hormone-sensitive lipase

The central role of adipose tissue hormone-sensitive lipase in regulating fatty acid metabolism makes it a potential pharmacological target for the prevention of peripheral insulin resistance in obese, prediabetic and diabetic individuals. The synthesis of a new series of carbazates is presented. Modification of the phenolic 4-position in a series of 1,2,3,4- tetrahydroisoquinoline and morpholine derived carbazates, yielded inhibitors of the catalytic activity of this enzyme with nanomolar potency.

Diuretic agents related to indapamide: III - Synthesis and pharmacological activity of N-(4-chloro-3-sulfamoylbenzamido)-1,2,3,4-tetrahydroquinolines 1,2,3,4-tetrahydroisoquinolines.

A series of N-(4-chloro-3-sulfamoylbenzamido)-1,2,3,4-tetrahydroquinoline (IV-1) and isoquinoline (IV-2) have been synthesized and their diuretic and antihypertensive activities evaluated. While none of the test compounds was found to be provided with ant

METAL-ASSISTED REACTIONS-PART 11 RAPID REDUCTION OF N-NITROSOAMINES TO N,N-DISUBSTITUTED HYDRAZINES; THE UTILITY OF SOME LOW-VALENT TITANIUM REAGENTS

The rapid reduction of N-nitrosoamines to N,N-disubstituted hydrazines by a low-valent titanium reagent is described.The reagent is selective in that many other functional groups are unaffected by it.The nature of the low-valent titanium reagent is discussed in terms of experimental results of comparisons of its reactivity and that of other low-valent titanium reducing agents.