484-78-6 Usage
Uses
Different sources of media describe the Uses of 484-78-6 differently. You can refer to the following data:
1. 3-Hydroxykynurenine is a metabolite of tryptophan.
ential endogenous neurotoxin.
2. 3-Hydroxy-DL-kynurenine has been used:as a substrate for the recombinant human kynureninase assay as a reference standard in tandem mass spectrometry (MS/MS) analysisas a control for quantifying serum 3-Hydroxy-DL-kynurenine levels in diabetic retinopathy patients
Definition
ChEBI: A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
General Description
3-Hydroxy-DL-kynurenine is a tryptophan metabolite with a molecular weight corresponding to 224Da. It is a chromophore or hydrophilic yellow compound present in the lens of the eye. 3-Hydroxy-DL-kynurenine is synthesized from kynurenine?by the action of enzyme kynurenine 3-monooxygenase (KMO). It is metabolized to 3-hydroxyanthranilic acid and xanthurenic acid in the presence of enzymes kynureninase and kynurenine aminotransferases, respectively.
Biochem/physiol Actions
3-Hydroxy-DL-kynurenine (3-HKYN) has antioxidant functionality and prevents lipid peroxidation in cerebral cortex. It may modulate synaptic neurotransmission. The levels of 3-HKYN is elevated in Huntington′s disease. However, its role in neurodegenerative diseases is still not understood well. Kynurenine metabolism is linked with glutamatergic neurotransmission and the level of 3-HKYN is linked to the pathophysiology of schizophrenia.
Check Digit Verification of cas no
The CAS Registry Mumber 484-78-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 4 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 484-78:
(5*4)+(4*8)+(3*4)+(2*7)+(1*8)=86
86 % 10 = 6
So 484-78-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2O4/c11-7-4-2-1-3-6(7)9(13)5-8(12-16)10(14)15/h1-4,8,12,16H,5,11H2,(H,14,15)/t8-/m0/s1
