484068-10-2

Upstream product

• 18424-76-5 sodiodimethylmalonate 
• 484068-09-9 carbonic acid tert-butyl ester 1-(3-nitro-phenyl)-allyl ester 
• 91004-30-7 α-vinyl-m-nitrobenzyl alcohol 

Downstream Products

• 484068-14-6 (R)-5-(4-Methoxy-benzyloxy)-2-[(S)-1-(3-nitro-phenyl)-allyl]-3-oxo-5-phenethyl-octanoic acid methyl ester 
• 484068-15-7 (R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-allyl]-3-oxo-5-phenethyl-octanoic acid methyl ester 
• 484068-16-8 (R)-4-Hydroxy-3-[(R)-1-(3-nitro-phenyl)-allyl]-6-phenethyl-6-propyl-5,6-dihydro-pyran-2-one 
• 484068-11-3 3-(3-nitrophenyl)pent-4-enoic acid methyl ester 

Relevant academic research and scientific papers

Utilization of molybdenum- and palladium-catayzed dynamic kinetic asymmetric transformations for the preparation of tertiary and quaternary stereogenic centers: A concise synthesis of Tipranavir

Tipranavir, an important antiviral agent in clinical development for the treatment of HIV, is synthesized in 15 linear steps from readily available starting materials in 25% overall yield by utilizing Pd- and Mo-catalyzed DYKAT reactions to control the qu