4842-86-8

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl piperidine-3-carboxylate hydrochloride is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the development of new drugs with different therapeutic properties.
Used in Agrochemical Industry:
Ethyl piperidine-3-carboxylate hydrochloride is used as a precursor in the synthesis of agrochemicals. Its versatility in chemical reactions enables the creation of compounds with potential applications in agriculture, such as pesticides and herbicides.
Used in Organic Chemical Synthesis:
Ethyl piperidine-3-carboxylate hydrochloride is used as a key intermediate in the synthesis of various organic compounds. Its ability to participate in a wide range of chemical reactions makes it a valuable component in the production of specialty chemicals and other industrial products.

Upstream product

• 5166-67-6 ethyl 1-methylpiperidine-3-carboxylate 
• 64-17-5 ethanol 
• 498-95-3 nipecotic acid 
• 148672-74-6 ethyl N-(t-butyloxycarbonyl)nipecotate 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 

Downstream Products

• 1156725-31-3 1-(2-Chloro-benzenesulfonyl)-piperidine-3-carboxylic acid ethyl ester 
• 148672-74-6 ethyl N-(t-butyloxycarbonyl)nipecotate 

Relevant academic research and scientific papers

HMPA-catalyzed transfer hydrogenation of 3-carbonyl pyridines and other N-heteroarenes with trichlorosilane

A method for the HMPA (hexamethylphosphoric triamide)-catalyzed metal-freetransfer hydrogenation of pyridines has been developed. The functional group tolerance of the existing reaction conditions provides easy access to various piperidines with ester or ketone groups at the C-3 site. The suitability of this method for the reduction of other N-heteroarenes has also been demonstrated. Thirty-three examples of different substrates have been reduced to designed products with 45–96% yields.

SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

JAK INHIBITOR

The present invention discloses a series of JAK inhibitors, and particularly discloses a compound of formula (I) or a pharmaceutically acceptable salt thereof and the use thereof in preparation of drugs for treating diseases related to JAK.

BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I) or Formula (II): wherein the variables Y, R1, R2, R3, and R4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

NOVEL INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I): wherein the variables Y, R1, R2, R3, R4 and R5 are as defined herein. Compounds described herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of such compounds and pharmaceutical compositions to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity

A General, Selective, High-Yield N-Demethylation Procedure for Tertiary Amines by Solid Reagents in a Convenient Column Chromatography-like Setup

(Equation presented) A traditional preparative chromatographic column can be used to achieve quantitative N-demethylation of tertiary N-methylamines and alkaloids. The filling is the crucial part and is loaded with different solid reagents in three reaction zones. The parent compound is charged on the column, and the neat N-demethylated secondary amine leaves the column some minutes later.