4842-86-8

Basic information

• Product Name: Ethyl piperidine-3-carboxylate hydrochloride
• Synonyms: ETHYL NIPECOTATE HYDROCHLORIDE;ETHYL 3-PIPERIDINECARBOXYLATE HYDROCHLORIDE;Ethyl 3-Piperidine-Carboxylate HCl;3-Piperidine Carboxylic Acid Ethyl Ester HCl;Ethyl 3-piperidinecarboxylicester hydrochloride;Ethyl piperidine-3-carboxylate hydrochloride;Ethyl piperidine-3-carboxylate HCl;RS-3-Piperidinecarboxylic acid ethyl ester hydrochloride
• CAS NO: 4842-86-8
• Molecular Formula: C₈H₁₅NO₂*ClH
• Molecular Weight: 193.67
• EINECS: 203-126-8
• Mol File: 4842-86-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 100-102°C
• Boiling Point: 254 °C at 760 mmHg
• Flash Point: 107.4 °C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Ethyl piperidine-3-carboxylate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl piperidine-3-carboxylate hydrochloride(4842-86-8)
• EPA Substance Registry System: Ethyl piperidine-3-carboxylate hydrochloride(4842-86-8)

Safety Data

• Hazardous Substances Data: 4842-86-8(Hazardous Substances Data)

Usage

General Description

Ethyl piperidine-3-carboxylate hydrochloride is a chemical compound with the molecular formula C10H18NO2Cl. It is a derivative of piperidine, a heterocyclic amine commonly used in pharmaceuticals and organic chemical synthesis. Ethyl piperidine-3-carboxylate hydrochloride is a white to off-white crystalline solid that is soluble in water and ethanol. It is used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Its specific properties and reactivity make it valuable for creating diverse chemical structures, and it is commonly utilized in the pharmaceutical and chemical industries.

Upstream product

• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 64-17-5 ethanol 
• 498-95-3 nipecotic acid 
• 5166-67-6 ethyl 1-methylpiperidine-3-carboxylate 
• 148672-74-6 ethyl N-(t-butyloxycarbonyl)nipecotate 

Downstream Products

• 1156725-31-3 1-(2-Chloro-benzenesulfonyl)-piperidine-3-carboxylic acid ethyl ester 
• 148672-74-6 ethyl N-(t-butyloxycarbonyl)nipecotate 

Relevant articles and documents

HMPA-catalyzed transfer hydrogenation of 3-carbonyl pyridines and other N-heteroarenes with trichlorosilane

A method for the HMPA (hexamethylphosphoric triamide)-catalyzed metal-freetransfer hydrogenation of pyridines has been developed. The functional group tolerance of the existing reaction conditions provides easy access to various piperidines with ester or ketone groups at the C-3 site. The suitability of this method for the reduction of other N-heteroarenes has also been demonstrated. Thirty-three examples of different substrates have been reduced to designed products with 45–96% yields.

JAK INHIBITOR

The present invention discloses a series of JAK inhibitors, and particularly discloses a compound of formula (I) or a pharmaceutically acceptable salt thereof and the use thereof in preparation of drugs for treating diseases related to JAK.

NOVEL INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I): wherein the variables Y, R1, R2, R3, R4 and R5 are as defined herein. Compounds described herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of such compounds and pharmaceutical compositions to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity