4842-87-9

Usage

Uses

Used in Pharmaceutical Industry:
Phenyl(piperidin-3-yl)methanone is used as a chemical intermediate for the synthesis of certain drugs, including analgesics and psychotropic agents, due to its ability to act as a precursor in their production process.
Used in Research and Chemical Synthesis:
Phenyl(piperidin-3-yl)methanone is used as a starting material to create new compounds and study their properties in research and chemical synthesis, contributing to the development of novel substances with potential applications.
It is important to handle phenyl(piperidin-3-yl)methanone with care, as it can be potentially hazardous and must be used in a controlled environment by trained professionals.

Upstream product

• 5424-19-1 3-Benzoylpyridine 

Downstream Products

• 1602924-10-6 phenyl(1-((S)-3,3,3-trifluoro-2-hydroxypropyl)piperidin-3-yl)methanone 

Relevant academic research and scientific papers

Method for preparing piperidine compound by reducing pyridine compound through hydrogen transfer

The invention discloses a method for preparing a piperazine compound through a hydrogen transfer reduction of a pyridine compound, belonging to the field of organic synthesis. Under mild conditions, pyridine derivatives are used as raw materials, oxazolidine is used as a hydrogen transfer reagent, and cheap transition metals such as copper, cobalt, silver, palladium and the like are used as catalysts for catalysis of a hydrogen transfer reaction on 1,2,3,4-substitution sites, so a series of hydrogen transfer reduction product piperidine compounds are prepared, wherein the oxazaborolidine is obtained by a reaction of amino acid with a tetrahydrofuran complex of borane. The method has the advantages that product yield is high, reaction conditions are mild, the general applicability of raw materials is good, a hydrogen transfer reagent is cheap and easy to obtain, and good reproducibility can still be shown after quantitative reaction is conudcted. Therefore, the method of the invention provides an effective scheme for the industrial production of other high-value compounds containing the structure in the future.

B(C6F5)3-Catalyzed Cascade Reduction of Pyridines

B(C6F5)3 has been found to be an effective catalyst for reduction of pyridines and other electron-deficient N-heteroarenes with hydrosilanes (or hydroboranes) and amines as the reducing reagents. The success of this development hinges upon the realization of a cascade process of dearomative hydrosilylation (or hydroboration) and transfer hydrogenation. The broad functional-group tolerance (e.g. ketone, ester, unactivated olefins, nitro, nitrile, heterocycles, etc.) implies high practical utility.