4844-51-3Relevant academic research and scientific papers
Highly Diastereoselective α-Arylation of Cyclic Nitriles
Dalziel, Michael E.,Chen, Penghao,Carrera, Diane E.,Zhang, Haiming,Gosselin, Francis
supporting information, p. 3446 - 3449 (2017/07/15)
A highly diastereoselective α-arylation of cyclic nitriles has been developed via a Negishi cross-coupling of commercially available aryl, heteroaryl, and alkenyl halides with cyclobutyl nitriles in the presence of tetramethylpiperidinylzinc chloride lithium chloride (TMPZnCl-LiCl) and catalytic XPhos-Pd-G2. A variety of electronically diverse electrophiles were well tolerated, and this chemistry was further advanced with application of both cyclopropyl and cyclopentyl nitriles.
Prototropic Isomerization of 1-Oxaspiro[2.3]hexane-5-carbonitrile and Methyl 1-Oxaspiro[2.3]hexane-5-carboxylate into the Corresponding 3-Hydroxymethylbicyclo[1.1.0]butane-1-carboxylic Acid Derivatives
Razin,Ulin
, p. 33 - 39 (2007/10/03)
Epoxy derivatives of 3-methylenecyclobutane-1-carbonitrile and methyl 3-methylenecyclobutane-1-carboxylate undergo isomerization into the corresponding 3-hydroxymethylbicyclobutane-1-carboxylic acid derivatives on treatment with lithium diisopropylamide in aprotic medium.
